Phenserine |
| Numéro de catalogue: GC13783 |
La phenserine ((-)-Eseroline phenylcarbamate) est un dérivé de la physostigmine et est un inhibiteur puissant, non compétitif, À action prolongée et sélectif de l'AChE.
Sample solution is provided at 25 µL, 10mM.
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(+)-Phenserine is a novel selective cholinesterase noncompetitive inhibitor with an IC50 of 45.3 μM.
References:
[1]. al-Jafari AA, et al. Kinetics of human erythrocyte acetylcholinesterase inhibition by a novel derivative of physostigmine: phenserine. Biochem Biophys Res Commun. 1998 Jul 9; 248(1):180-5.
| Cas No. | 101246-66-6 | SDF | |
| Chemical Name | (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl phenylcarbamate | ||
| Canonical SMILES | O=C(NC1=CC=CC=C1)OC2=CC3=C(C=C2)N(C)[C@H]4N(C)CC[C@]43C | ||
| Formula | C20H23N3O2 | M.Wt | 337.42 |
| Solubilité | DMF: 25 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml,Ethanol: 25 mg/ml | Storage | Store at -20°C |
| Conseils généraux | Afin d'obtenir une solubilité plus élevée, veuillez chauffer le tube à 37 °C et le secouer dans le bain à ultrasons pendant un certain temps. La solution mère peut être conservée à une température inférieure à -20 °C pendant plusieurs mois. | ||
| Condition d'expédition | Solution d'échantillon d'évaluation : livré avec la glace bleue Toute autre taille disponible : livré avec RT ou la glace bleue sur demande |
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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