Picotamide |
| Catalog No.GC18323 |
Le picotamide est un inhibiteur combiné de la synthase et du récepteur de la thromboxane A2 (TxA2).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 32828-81-2
Sample solution is provided at 25 µL, 10mM.
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Picotamide is an antiplatelet drug that inhibits both thromboxane A2 (TXA2) receptors (Kd = 325 nM) and TXA2 synthase.[1] [2] It significantly inhibits basal and lipopolysaccharide-stimulated TXA2 synthesis by rat peritoneal macrophages when used at 0.5 mM.[3] Formulations containing picotamide have potential applications in the reduction of peripheral artery disease in patients with diabetes.[1]
Reference:
[1]. Celestini, A., and Violi, F. A review of picotamide in the reduction of cardiovascular events in diabetic patients. Vasc. Health Risk Manag. 3(1), 93-98 (2008).
[2]. Modesti, P.A., Cecioni, I., Colella, A., et al. Binding kinetics and antiplatelet activities of picotamide, a thromboxane A2 receptor antagonist. Br. J. Pharmacol. 112(1), 81-86 (1994).
[3]. Matera, G., Chisari, M., Altavilla, D., et al. Selective thromboxane synthetase inhibition by picotamide and effects on endotoxin-induced lethality. Proc. Soc. Exp. Biol. Med. 187(1), 58-61 (1988).
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