DDR1-IN-1 (hydrate) (Synonyms: Discoidin Domain Receptor 1-IN-1) |
| Catalog No.GC43389 |
The discoidin domain receptor (DDR) tyrosine kinases are activated by matrix collagens and are important for cell proliferation, differentiation, adhesion, migration, and invasion.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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The discoidin domain receptor (DDR) tyrosine kinases are activated by matrix collagens and are important for cell proliferation, differentiation, adhesion, migration, and invasion. DDR1-IN-1 binds to DDR1 and inhibits DDR1 autophosphorylation with an IC50 value of 105 nM and an EC50 value of 87 nM. It demonstrates weaker inhibition for DDR2 (IC50 = 413 nM) and has a good selectivity profile against a panel of 451 kinases. DDR-IN-1 has been shown to inhibit colorectal cancer cell lines when used in combination with the PI3K/mTOR inhibitor, GSK2126458 .
Average Rating: 5 (Based on Reviews and 13 reference(s) in Google Scholar.)
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