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Piperafizine A

Catalog No.GC41629

La pipérafizine A (composé 4d') est un dérivé de plinabuline N-monoalkylé. Réactif anticancéreux.

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Piperafizine A Chemical Structure

Cas No.: 130603-59-7

Taille Prix Stock Qté
1mg
375,00 $US
En stock
5mg
1 191,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Piperafizine A is a natural methylated diketopiperazine first isolated from an actinomycete, Streptoverticillium. It potentiates the cytotoxicity of vincristine , an anti-cancer alkaloid known to be exported from cells by P-glycoprotein. Piperafizine A directs the intracellular accumulation of vincristine in cancer cells to a similar degree as verapamil , a P-glycoprotein inhibitor. The effects of piperafizine A on vincristine accumulation in cancer cells is dose-dependent over a range of 1 to 20 µg/ml.

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Average Rating: 5 ★★★★★ (Based on Reviews and 27 reference(s) in Google Scholar.)

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