Piperafizine A |
| Katalog-Nr.GC41629 |
Piperafizin A (Verbindung 4d') ist ein N-monoalkyliertes Plinabulin-Derivat. Anti-Krebs-Reagenz.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 130603-59-7
Sample solution is provided at 25 µL, 10mM.
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Piperafizine A is a natural methylated diketopiperazine first isolated from an actinomycete, Streptoverticillium. It potentiates the cytotoxicity of vincristine , an anti-cancer alkaloid known to be exported from cells by P-glycoprotein. Piperafizine A directs the intracellular accumulation of vincristine in cancer cells to a similar degree as verapamil , a P-glycoprotein inhibitor. The effects of piperafizine A on vincristine accumulation in cancer cells is dose-dependent over a range of 1 to 20 µg/ml.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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