PROTAC Sirt2 Degrader-1 |
| Catalog No.GC33418 |
PROTAC Sirt2 Degrader-1 est un PROTAC basé sur SirReal, agit comme un dégradeur de Sirt2, composé d'un inhibiteur de Sirt2 très puissant et isotype sélectif, d'un lieur et d'un véritable ligand Cereblon pour l'ubiquitine ligase E3. PROTAC Sirt2 Degrader-1 montre une IC50 de 0,25 μM pour Sirt2, sans effet sur Sirt1/Sirt3 (IC50s>100 μM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2098487-75-1
Sample solution is provided at 25 µL, 10mM.
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PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker and thalidomide, a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1].
PROTAC Sirt2 Degrader-1 (Compound 12; 10 µM, 1-6 hours) induces Sirt2 degradation in HeLa cells[1].|| Western Blot Analysis[1]||Cell Line:|HeLa cells|Concentration:|10 µM|Incubation Time:|1-6 hours|Result:|Caused Sirt2 degradation, but showed no effect on Sirt1 levels.
[1]. Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.
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