PROTAC Sirt2 Degrader-1 |
| カタログ番号GC33418 |
PROTAC Sirt2 Degrader-1 は、SirReal ベースの PROTAC であり、非常に強力でアイソタイプ選択的な Sirt2 阻害剤、リンカー、および E3 ユビキチン リガーゼに対する正真正銘のセレブロン リガンドで構成される Sirt2 デグレーダーとして機能します。 PROTAC Sirt2 Degrader-1 は、Sirt2 に対して 0.25 μM の IC50 を示し、Sirt1/Sirt3 には影響しません (IC50 > 100 μM)。
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Cas No.: 2098487-75-1
Sample solution is provided at 25 µL, 10mM.
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PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker and thalidomide, a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1].
PROTAC Sirt2 Degrader-1 (Compound 12; 10 µM, 1-6 hours) induces Sirt2 degradation in HeLa cells[1].|| Western Blot Analysis[1]||Cell Line:|HeLa cells|Concentration:|10 µM|Incubation Time:|1-6 hours|Result:|Caused Sirt2 degradation, but showed no effect on Sirt1 levels.
[1]. Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.
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