Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) (Synonyms: GLYX-13 Trifluoroacetate) |
| Catalog No.GC33492 |
Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) (GLYX-13 Trifluoroacetate) est un modulateur des récepteurs NMDA avec des propriétés agonistes partielles du site glycine.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1435786-04-1
Sample solution is provided at 25 µL, 10mM.
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Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties and currently in a phase II clinical development program as an adjunctive therapy for major depressive disorder.
Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties and currently in a phase II clinical development program as an adjunctive therapy for major depressive disorder. Mice given Rapastinel Trifluoroacetate (1.0 mg/kg) prior to acute ketamine (30 mg/kg) show clear preference for novel compare to familiar objects (P0.05][2].
[1]. Rajagopal L, et al. GLYX-13 (rapastinel) ameliorates subchronic phencyclidine- and ketamine-induced declarative memory deficits in mice. Behav Brain Res. 2016 Feb 15;299:105-10. [2]. Burgdorf J, et al. The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus. Neuroscience. 2015 Nov 12;308:202-11.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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