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Chromatin/Epigenetics

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Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Research Areas

Products Related to Chromatin/Epigenetics(1851)

  • GC79150 structure
    GC79150NV914
    CAS: 2341941-41-9
    Purity: >98.50%

    NV914 is an inhibitor of FTSJ1 (tryptophan tRNA-specific 2'-O-methyltransferase) that inhibits the methyltransferase activity of FTSJ1, induces translational readthrough of premature termination codons, and enables genes carrying nonsense mutations to synthesize full-length proteins.

  • GC79151 structure
    GC79151DLG-41
    Purity: >98.00%

    DLG-41 is a GAS41 YEATS domain inhibitor ( IC 50 : 600 nM in AlphaLISA).

  • GC79152 structure
    GC79152cis-Revumenib
    Purity: >98.50%

    cis-Revumenib (cis-SNDX-5613) is an isomer of Revumenib.

  • GC79153 structure
    GC79153LS-170
    CAS: 3099617-79-2
    Purity: >99.50%

    LS-170 is a YEATS2 YEATS domain inhibitor with an IC 50 of 0.14 μM.

  • GC79154 structure
    GC79154BAY-7728
    CAS: 2767642-46-4
    Purity: >98.50%

    BAY-7728 is an orally active and selective dual inhibitor of KAT6A ( IC 50 : 45 nM)/ KAT6B ( IC 50 : 95 nM).

  • GC79155 structure
    GC79155Omvitrastat
    CAS: 3056105-63-3
    Purity: >99.50%

    Omvitrastat (OP-3136) is an orally active, highly selective inhibitor of KAT6A and KAT6B.

  • GC79156 structure
    GC79156SYY-B029-2
    CAS: 2379410-19-0
    Purity: >99.50%

    SYY-B029-2 is a potent histone acetyltransferase (HAT) inhibitor with an IC 50 of 1.4 nM.

  • GC79157 structure
    GC79157KDM4C-IN-2
    CAS: 23705-85-3
    Purity: >98.00%

    KDM4C-IN-2 is a histone lysine demethylase KDM4C ( JMJD2C ) inhibitor with an IC 50 of 147 μM and a K i of 51 μM.

  • GC79158 structure
    GC79158TNG917
    CAS: 2923223-81-6
    Purity: >98%

    TNG917 is a potent, selective EHMT1/2 inhibitor with oral activity.

  • GC79159 structure
    GC79159EZM8266
    CAS: 2140164-84-5
    Purity: >98.00%

    EZM8266 is an orally active and selective G9a ( EHMT2 ) histone methyltransferase inhibitor with a human EHMT2 IC 50 of 1 pM.

  • GC79160 structure
    GC79160TNG456
    CAS: 2962087-36-9
    Purity: >98%

    TNG456 is an orally active, CNS-penetrant, selective, MTA-cooperative PRMT5 inhibitor.

  • GC79161 structure
    GC79161MS2928
    Purity: >98%

    MS2928 is a selective SETD8 inhibitor with an IC 50 of 0.14 μM against SETD8 methyltransferase activity.

  • GC79162 structure
    GC79162NSD2-IN-5
    CAS: 2604513-53-1
    Purity: >98.50%

    NSD2-IN-5 (Compound 198) is a SET domain-containing nuclear protein 2 ( NSD2 ) inhibitor with an IC 50 value ranging from 0.001 μM to 0.01 μM.

  • GC79163 structure
    GC79163UNC6535 TFA
    Purity: >99.00%

    UNC6535 TFA is a covalent ligand targeting the triple Tudor domain (3TD) of SETDB1.

  • GC79164 structure
    GC79164LLC0424N
    CAS: 3063448-59-6
    Purity: >98.00%

    LLC0424 N is a negative control compound designed by methylating the thalidomide moiety of LLC0424.

  • GC79165 structure
    GC79165Snail IN-1
    CAS: 3083216-69-4
    Purity: >98.00%

    Snail IN-1 is an orally active Snail inhibitor with a Ka of 0.36 μM.Snail IN-1 disrupts Snail - CBP interaction, accelerates Snail protein degradation, reduces Snail acetylation, increases Snail polyubiquitination, and selectively downregulates Snail protein without altering other EMT transcription factors.Snail IN-1 reduces atherosclerotic plaque burden, modulates inflammation and plaque stability factors, downregulates CCL5, CXCL10, MMP2, and MMP9, and upregulates α-smooth muscle actin.Snail IN-1 exerts anti-inflammatory and plaque-stabilizing properties.Snail IN-1 can be used for the research of atherosclerosis [1] .

  • GC79167 structure
    GC79167METTL1-WDR4-IN-1 TFA
    Purity: >99.50%

    METTL1-WDR4-IN-1 (Compound 1) TFA is a selective competitive inhibitor of the methyltransferase complex METTL1-WDR4 ( IC 50 =144 μM).

  • GC79168 structure
    GC79168EP102
    CAS: 3050818-07-7
    Purity: >98%

    EP102 is an orally active, selective inhibitor of the METTL3/METTL14 complex with an IC 50 of 2 nM.

  • GC79169 structure
    GC79169Lepodisiran
    CAS: 2808361-18-2
    Purity: >91.50%

    Lepodisiran (LY3819469) is a GalNAc-conjugated small interfering RNA lipid-lowering agent.

  • GC79170 structure
    GC79170Farabursen sodium
    CAS: 2921918-19-4
    Purity: >93.50%

    Farabursen sodium (RGLS8429 sodium; RG1015 sodium) is a miR-17 inhibitor.

  • GC79171 structure
    GC79171Farabursen sodium scrambled negative control
    Purity: >96.00%

    Farabursen sodium scrambled negative control is the sequence scrambled negative control of Farabursen sodium.

  • GC79172 structure
    GC79172Mivelsiran sodium
    Purity: >95.00%

    Mivelsiran (ALN-APP) sodium is an siRNA targeting the β-amyloid precursor protein ( APP ).

  • GC79173 structure
    GC79173SH6
    CAS: 2619408-35-2
    Purity: >99.00%

    SH6 is a CRBN -dependent proteasome degrader that targets ZBTB7A.

  • GC79174 structure
    GC79174(S)-NSD2-IN-5
    Purity: >99.50%

    (S)-NSD2-IN-5 is the S-isomer of NSD2-IN-5.