Chromatin/Epigenetics
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Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
Research Areas
- Bromodomain(44)
- Aurora Kinase(72)
- DNA Methyltransferase(41)
- HDAC(242)
- Histone Acetyltransferases(92)
- Histone Demethylases(116)
- Histone Methyltransferase(262)
- HIF(124)
- JAK(177)
- PARP(152)
- Pim(32)
- Protein Ser/Thr Phosphatases(23)
- RNA Polymerase(4)
- Sirtuin(81)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(20)
- Epigenetic Reader Domain(279)
- MicroRNA(30)
- Protein Arginine Deiminase(17)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(43)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(14)
- METTL3(4)
- WDR5(3)
- TET Protein(2)
- HuR(1)
- SF3B1(2)
Products Related to Chromatin/Epigenetics(1851)
- GC79178BRD4 degrader-7Purity: >98%
BRD4 degrader-7 (Compound ZZ1) is a CTLH -dependent BRD4 degrader and c-Glue with a DC 50 of 489 nM.
- GC79179WIZ degrader 8 TFAPurity: >99.00%
WIZ degrader 8 (TFA) is the trifluoroacetic acid of WIZ degrader 8.
- GC79183CGN peptide TFAPurity: >98.00%
CGN peptide TFA is a 13 amino acid peptide composed of D-amino acids, referred to as CGN peptide.
- GC79184Elebsiran scramble negative controlPurity: >98.00%
Elebsiran scramble negative control is the scrambled sequence of Elebsiran, and its modification method is the same.
- GC79185Vutrisiran sodium scrambled negative controlPurity: >93.50%
Vutrisiran sodium scrambled negative control is the sequence scrambled negative control of Vutrisiran sodium.
- GC79189Z116334910CAS: 412940-42-2Purity: >99.00%
Z116334910 is a promising WDR5-MLL1 interaction disruptor.
- GC79370PD-L1/HDAC6-IN-1 TFAPurity: >99.50%
PD-L1/HDAC6-IN-1 TFA is an orally active dual inhibitor of PD-L1 and HDAC6, with IC 50 values of 26.8 nM and 78 nM, respectively.
- GC79577PFKFB4-IN-1CAS: 2664831-55-2Purity: >99.50%
PFKFB4-IN-1 is a potent and selective ATP-competitive PFKFB4 inhibitor ( IC 50 = 4.50 μM) that reduces intracellular PFKFB4 protein levels.
- GC79669PHD-1-IN-4CAS: 2009343-19-3Purity: >99.50%
PHD-1-IN-4 is a brain-penetrant PHD-1 inhibitor with an IC 50 of 0.074 μM [1] .
- GC797782-PhenylcyclopropanamineCAS: 54-97-7Purity: >98.50%
2-Phenylcyclopropanamine (Compound 3) is an irreversible inhibitor of MAO-A/B and LSD1.
- GC79816CryptolepineCAS: 480-26-2Purity: >98%
Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties.
- GC79871CHNQD-00824CAS: 2222643-74-3Purity: >98%
CHNQD-00824 is a Terphenyllin derivative with potent anticancer effect.
- GC80333Ac-QPKK(Ac)-AMC acetatePurity: >99.00%
Ac-QPKK(Ac)-AMC acetate is a p53-derived peptide conjugated with a fluorophore, which serves as a fluorescent peptide substrate for detecting the deacylase activity of zinc-dependent HDACs and sirtuins (Ex = 360 nm; Em = 460 nm) [1] .
- GC80334Rucaparib-d 3CAS: 2271225-13-7Purity: >98.00%
Rucaparib -d 3 (AG014699-d 3 ) is the deuterated -labeled Rucaparib.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC79178 | BRD4 degrader-7 | - | >98% | |
BRD4 degrader-7 (Compound ZZ1) is a CTLH -dependent BRD4 degrader and c-Glue with a DC 50 of 489 nM. | ||||
| GC79179 | WIZ degrader 8 TFA | - | >99.00% | |
WIZ degrader 8 (TFA) is the trifluoroacetic acid of WIZ degrader 8. | ||||
| GC79180 | YZ-836P | 3086041-35-9 | >98.00% | |
YZ-836P is a Protein arginine methyltransferase 5 ( PRMT5 ) targeting agent. | ||||
| GC79181 | RAI-20 | 2549180-90-5 | >98.50% | |
RAI-20 (H018) is an orally active JAK1/JAK2 dual inhibitor ( IC 50 =15.1 and 22.7 nM). | ||||
| GC79182 | WX-02-43 | 2929223-36-7 | >99.50% | |
WX-02-43 is a weak covalent inhibitor of SF3B1, and is the (1S,3R) enantiomer of WX-02-23. | ||||
| GC79183 | CGN peptide TFA | - | >98.00% | |
CGN peptide TFA is a 13 amino acid peptide composed of D-amino acids, referred to as CGN peptide. | ||||
| GC79184 | Elebsiran scramble negative control | - | >98.00% | |
Elebsiran scramble negative control is the scrambled sequence of Elebsiran, and its modification method is the same. | ||||
| GC79185 | Vutrisiran sodium scrambled negative control | - | >93.50% | |
Vutrisiran sodium scrambled negative control is the sequence scrambled negative control of Vutrisiran sodium. | ||||
| GC79188 | TAS1440 | 2098585-77-2 | >98.00% | |
TAS1440 is an orally active LSD1/KDM1A inhibitor with a human IC 50 of 4.8 nM. | ||||
| GC79189 | Z116334910 | 412940-42-2 | >99.00% | |
Z116334910 is a promising WDR5-MLL1 interaction disruptor. | ||||
| GC79370 | PD-L1/HDAC6-IN-1 TFA | - | >99.50% | |
PD-L1/HDAC6-IN-1 TFA is an orally active dual inhibitor of PD-L1 and HDAC6, with IC 50 values of 26.8 nM and 78 nM, respectively. | ||||
| GC79451 | JP-11646 | 1902983-63-4 | >98.50% | |
JP-11646 is a pan-PIM inhibitor with increased potency against PIM2 ( IC 50 = 0.5 nM). | ||||
| GC79477 | KZ-02 | 1801756-14-8 | >98.00% | |
KZ-02 is an orally active dual MEK1 / Pim-1 kinase inhibitor, with an IC 50 of 1.07 nM against MEK1 and an IC 50 of 1.34 μM against Pim-1. | ||||
| GC79574 | mCPX | 1351572-56-9 | >98% | |
mCPX is a prodrug of the antifungal agent Ciclopirox olamine (CPX). | ||||
| GC79577 | PFKFB4-IN-1 | 2664831-55-2 | >99.50% | |
PFKFB4-IN-1 is a potent and selective ATP-competitive PFKFB4 inhibitor ( IC 50 = 4.50 μM) that reduces intracellular PFKFB4 protein levels. | ||||
| GC79669 | PHD-1-IN-4 | 2009343-19-3 | >99.50% | |
PHD-1-IN-4 is a brain-penetrant PHD-1 inhibitor with an IC 50 of 0.074 μM [1] . | ||||
| GC79670 | ZG-2686 | 1795110-22-3 | >98% | |
ZG-2686 is a potent and selective HIF-2α agonist with an EC 50 of 0.25 µM. | ||||
| GC79671 | HIF-IN-2 | 1040535-05-4 | >95.00% | |
HIF-IN-2 is a HIF/HIF prolyl hydroxylase inhibitor. | ||||
| GC79778 | 2-Phenylcyclopropanamine | 54-97-7 | >98.50% | |
2-Phenylcyclopropanamine (Compound 3) is an irreversible inhibitor of MAO-A/B and LSD1. | ||||
| GC79816 | Cryptolepine | 480-26-2 | >98% | |
Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties. | ||||
| GC79871 | CHNQD-00824 | 2222643-74-3 | >98% | |
CHNQD-00824 is a Terphenyllin derivative with potent anticancer effect. | ||||
| GC80333 | Ac-QPKK(Ac)-AMC acetate | - | >99.00% | |
Ac-QPKK(Ac)-AMC acetate is a p53-derived peptide conjugated with a fluorophore, which serves as a fluorescent peptide substrate for detecting the deacylase activity of zinc-dependent HDACs and sirtuins (Ex = 360 nm; Em = 460 nm) [1] . | ||||
| GC80334 | Rucaparib-d 3 | 2271225-13-7 | >98.00% | |
Rucaparib -d 3 (AG014699-d 3 ) is the deuterated -labeled Rucaparib. | ||||
| GC80335 | (S)-ML399 | 1560968-51-5 | >99.50% | |
(S)-ML399 (Compound 18S) is the enantiomer of ML399. | ||||