Chromatin/Epigenetics
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Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
Research Areas
- Bromodomain(44)
- Aurora Kinase(72)
- DNA Methyltransferase(41)
- HDAC(242)
- Histone Acetyltransferases(92)
- Histone Demethylases(116)
- Histone Methyltransferase(262)
- HIF(124)
- JAK(177)
- PARP(152)
- Pim(32)
- Protein Ser/Thr Phosphatases(23)
- RNA Polymerase(4)
- Sirtuin(81)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(20)
- Epigenetic Reader Domain(279)
- MicroRNA(30)
- Protein Arginine Deiminase(17)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(43)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(14)
- METTL3(4)
- WDR5(3)
- TET Protein(2)
- HuR(1)
- SF3B1(2)
Products Related to Chromatin/Epigenetics(1851)
- GC80336(R)-JQ-1 carboxylic acidCAS: 202592-24-3Purity: >99.00%
(R)-JQ-1 carboxylic acid, is an isomer of JQ-1 carboxylic acid.
- GC80468Peficitinib-d 3Purity: >98%
Peficitinib -d 3 (ASP015K-d 3 ) is the deuterium labeled Peficitinib.
- GC80477Sodium butyrate-d 3CAS: 347840-05-5Purity: >99.50%
Sodium butyrate -d 3 (Butanoic acid-d 3 sodium) is the deuterium labeled Sodium butyrate.
- GC80857Enzomenib enantiomerPurity: >98.00%
Enzomenib enantiomer (DSP-5336 enantiomer) is an enantiomer of Enzomenib.
- GC80875PROTAC survivin degrader-1CAS: 3079079-69-6Purity: >98%
PROTAC survivin degrader-1 is an orally active, CNS-penetrant survivin -targeting PROTAC.
- GC80877LD-110 triTFAPurity: >99.50%
LD-110 triTFA is a highly efficient and effective LSD1 PROTAC degrader ( DC 50 = 0.44 μM).
- GC80889PROTAC HDAC4 Degrader-2CAS: 3035189-46-6Purity: >98%
PROTAC HDAC4 Degrader-2 is a class IIa selective negative control for HDAC4 PROTAC degraders, with an IC 50 of 0.15 μM against HDAC4 and a cellular IC 50 of 0.18 μM.
- GC80917LD-110 trihydrochloridePurity: >98.00%
LD-110 trihydrochloride is a highly efficient and effective LSD1 PROTAC degrader ( DC 50 = 0.44 μM).
- GC80919AURKA-IN-4CAS: 89575-11-1Purity: >99.50%
AURKA-IN-4 is a Capsaicin -derived molecular glue targeting AURKA-PHB2, and acts as an inhibitor of Aurora kinase A ( AURKA ) and PHB2.
- GC80920PROTAC PARP2 degrader-1CAS: 2925182-32-5Purity: >95.50%
PROTAC PARP2 degrader-1 is an orally active PARP2 PROTAC degrader with a DC 50 of 2 μM.
- GC80922PROTAC HDAC6 degrader 7Purity: >98%
PROTAC HDAC6 degrader 7 is an orally active, highly efficient, and selective PROTAC degrader targeting histone deacetylase 6 ( HDAC6 ) ( IC 50 = 118 nM).
- GC80923PROTAC HDAC degrader-2 TFAPurity: >96.50%
PROTAC HDAC degrader-2 TFA is a selective class IIb dual histone deacetylase ( HDAC6 and HDAC10 ) PROTAC degrader, with DC 50 values of 13 nM and 29 nM against HDAC6 and HDAC10, respectively.
- GC80924iVeliparib-AP6CAS: 2472645-27-3Purity: >98%
iVeliparib-AP6 is a proteolysis-targeting chimera ( PROTAC ) molecule designed based on Veliparib, which targets PARP1/2.
- GC80925KAT2A/B ligand 1CAS: 2254066-18-5Purity: >99.00%
KAT2A/B ligand 1 (compound 32a) is a KAT2A/B ligand.
- GC80926BI-7273 acidCAS: 2097514-90-2Purity: >98.00%
BI-7273 acid, BI-7273 derivative, is a BRD9 PROTAC ligand.
- GC80927NSD2 ligand 2CAS: 3031353-62-2Purity: >98.50%
NSD2 ligand 2 is a ligand for target protein for PROTAC that specifically binds to NSD2.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC80336 | (R)-JQ-1 carboxylic acid | 202592-24-3 | >99.00% | |
(R)-JQ-1 carboxylic acid, is an isomer of JQ-1 carboxylic acid. | ||||
| GC80468 | Peficitinib-d 3 | - | >98% | |
Peficitinib -d 3 (ASP015K-d 3 ) is the deuterium labeled Peficitinib. | ||||
| GC80477 | Sodium butyrate-d 3 | 347840-05-5 | >99.50% | |
Sodium butyrate -d 3 (Butanoic acid-d 3 sodium) is the deuterium labeled Sodium butyrate. | ||||
| GC80483 | IOX2-NH2 | 931400-77-0 | >98.00% | |
IOX2 -NH2 (example 115) is a derivative of IOX2. | ||||
| GC80854 | (R)-BMS-986470 | - | >99.50% | |
(R)-BMS-986470 is the enantiomer of BMS-986470. | ||||
| GC80857 | Enzomenib enantiomer | - | >98.00% | |
Enzomenib enantiomer (DSP-5336 enantiomer) is an enantiomer of Enzomenib. | ||||
| GC80875 | PROTAC survivin degrader-1 | 3079079-69-6 | >98% | |
PROTAC survivin degrader-1 is an orally active, CNS-penetrant survivin -targeting PROTAC. | ||||
| GC80876 | G9D-4 TFA | - | >99.00% | |
G9D-4 TFA is a G9a PROTAC degrader. | ||||
| GC80877 | LD-110 triTFA | - | >99.50% | |
LD-110 triTFA is a highly efficient and effective LSD1 PROTAC degrader ( DC 50 = 0.44 μM). | ||||
| GC80889 | PROTAC HDAC4 Degrader-2 | 3035189-46-6 | >98% | |
PROTAC HDAC4 Degrader-2 is a class IIa selective negative control for HDAC4 PROTAC degraders, with an IC 50 of 0.15 μM against HDAC4 and a cellular IC 50 of 0.18 μM. | ||||
| GC80916 | ZX079 | 3124583-65-6 | >98% | |
ZX079 is a dual BRD4 and CBP PROTAC degrader with a BRD4 DC 50 value of 0.035 nM and a CBP DC 50 value of < 0.02 nM. | ||||
| GC80917 | LD-110 trihydrochloride | - | >98.00% | |
LD-110 trihydrochloride is a highly efficient and effective LSD1 PROTAC degrader ( DC 50 = 0.44 μM). | ||||
| GC80918 | dCBP-30 | - | >98% | |
dCBP-30 is an orally active, selective and dual-acting CBP/p300 PROTAC degrader with DC 50 values of 0.05 nM (CBP) and 0.04 nM (p300), respectively. | ||||
| GC80919 | AURKA-IN-4 | 89575-11-1 | >99.50% | |
AURKA-IN-4 is a Capsaicin -derived molecular glue targeting AURKA-PHB2, and acts as an inhibitor of Aurora kinase A ( AURKA ) and PHB2. | ||||
| GC80920 | PROTAC PARP2 degrader-1 | 2925182-32-5 | >95.50% | |
PROTAC PARP2 degrader-1 is an orally active PARP2 PROTAC degrader with a DC 50 of 2 μM. | ||||
| GC80921 | CCT400028 | - | >98.00% | |
CCT400028 is a PROTACs -class degrader that targets the Aurora A (AURKA) kinase. | ||||
| GC80922 | PROTAC HDAC6 degrader 7 | - | >98% | |
PROTAC HDAC6 degrader 7 is an orally active, highly efficient, and selective PROTAC degrader targeting histone deacetylase 6 ( HDAC6 ) ( IC 50 = 118 nM). | ||||
| GC80923 | PROTAC HDAC degrader-2 TFA | - | >96.50% | |
PROTAC HDAC degrader-2 TFA is a selective class IIb dual histone deacetylase ( HDAC6 and HDAC10 ) PROTAC degrader, with DC 50 values of 13 nM and 29 nM against HDAC6 and HDAC10, respectively. | ||||
| GC80924 | iVeliparib-AP6 | 2472645-27-3 | >98% | |
iVeliparib-AP6 is a proteolysis-targeting chimera ( PROTAC ) molecule designed based on Veliparib, which targets PARP1/2. | ||||
| GC80925 | KAT2A/B ligand 1 | 2254066-18-5 | >99.00% | |
KAT2A/B ligand 1 (compound 32a) is a KAT2A/B ligand. | ||||
| GC80926 | BI-7273 acid | 2097514-90-2 | >98.00% | |
BI-7273 acid, BI-7273 derivative, is a BRD9 PROTAC ligand. | ||||
| GC80927 | NSD2 ligand 2 | 3031353-62-2 | >98.50% | |
NSD2 ligand 2 is a ligand for target protein for PROTAC that specifically binds to NSD2. | ||||
| GC80928 | NP1192 | 2966791-41-1 | >99.00% | |
NP1192 is a potent, selective PROTAC NAT10 degrader. | ||||
| GC80929 | PLX-4104 | 2851986-77-9 | >98% | |
PLX-4104 is an orally active BRD4 molecular glue degrader with a DC 50 of 2 nM. | ||||