Chromatin/Epigenetics
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Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
Research Areas
- Bromodomain(44)
- Aurora Kinase(71)
- DNA Methyltransferase(41)
- HDAC(233)
- Histone Acetyltransferases(92)
- Histone Demethylases(112)
- Histone Methyltransferase(262)
- HIF(123)
- JAK(173)
- PARP(149)
- Pim(32)
- Protein Ser/Thr Phosphatases(23)
- RNA Polymerase(4)
- Sirtuin(81)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(20)
- Epigenetic Reader Domain(277)
- MicroRNA(29)
- Protein Arginine Deiminase(17)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(43)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(14)
- METTL3(4)
- WDR5(3)
- TET Protein(2)
- HuR(1)
- SF3B1(2)
Products Related to Chromatin/Epigenetics(1827)
- GC81536BraxlosiranPurity: >95.00%
Braxlosiran is a component of the AOC reagent Delpacibart braxlosiran, consisting of an siRNA targeting DUX4 (double homeobox protein) and SMCC linker.
- GC81557Zilebesiran sodiumCAS: 2380166-34-5Purity: >94.50%
Zilebesiran (AD-85481; ALN-AGT) sodium is a long-acting liver-targeted small interfering RNA (siRNA) antihypertensive agent.
- GC815842-Amino-2-deoxy-D-glucopyranoseCAS: 90-77-7Purity: >98.00%
2-Amino-2-deoxy-D-glucopyranose is an isomeric form of Glucosamine.
- GC81602Glucosamine sulfate potassium chlorideCAS: 1296149-08-0Purity: >98.00%
Glucosamine sulfate potassium chloride is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement.
- GC81628Nicotinamide- 13 C, 15 NPurity: >98.50%
Nicotinamide - 13 C, 15 N (Niacinamide- 13 C, 15 N) is the 13 C- and 15 N-labeled Nicotinamide.
- GC81658FAM-hsa-miR-147b-5p mimicPurity: >98.00%
FAM-hsa-miR-147b-5p mimic is a FAM-labeled hsa-miR-147b-5p mimic.
- GC81659GAPDH Positive Control siRNA (Human)Purity: >98.00%
GAPDH Positive Control siRNA (Human), a siRNA product, is a human GAPDH siRNA positive control.
- GC81660GAPDH siRNA Positive Control (Mouse/Rat)Purity: >98.00%
GAPDH siRNA Positive Control (Mouse/Rat), a siRNA product, is a mouse/rat GAPDH siRNA positive control.
- GC81676Endosidin7CAS: 329072-88-0Purity: >98%
Endosidin7 is a specific inhibitor for plant callose deposition during cytokinesis.
- GC81685GDP-azido-fucose disodiumCAS: 944560-34-3Purity: >99.50%
GDP-azido-fucose disodium is a glycoengineering tool.
- GC81705(R)-I-BET762 carboxylic acid (Standard)CAS: 1786401-70-4Purity: >98.00%
(R)-I-BET762 carboxylic acid (Standard) is the analytical standard of (R)-I-BET762 carboxylic acid.
- GC81758HDAC11-IN-5Purity: >98.00%
HDAC11-IN-5 is a selective, potent and orally active HDAC11 inhibitor with an IC 50 of 0.021 μM.
- GC818224-Chloro-N-methylpicolinamide-d₃CAS: 1189858-48-7Purity: >98.00%
4-Chloro-N-methylpicolinamide -d 3 is the deuterated-labeled 4-Chloro-N-methylpicolinamide.
- GC81837Histone H4 peptide substrate (1-21) acetatePurity: >98.00%
Histone H4 peptide substrate (1-21) acetate is a PAD4 peptide substrate.
- GC81867Ac-ETDK(myr)-AMC acetatePurity: >98.00%
Ac-ETDK(myr)-AMC acetate is a DLAT-derived ε-N-myristoyllysine peptide substrate for fatty-acid deacylase HDAC11, used in fluorescence-based HDAC11 activity assays.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC81536 | Braxlosiran | - | >95.00% | |
Braxlosiran is a component of the AOC reagent Delpacibart braxlosiran, consisting of an siRNA targeting DUX4 (double homeobox protein) and SMCC linker. | ||||
| GC81557 | Zilebesiran sodium | 2380166-34-5 | >94.50% | |
Zilebesiran (AD-85481; ALN-AGT) sodium is a long-acting liver-targeted small interfering RNA (siRNA) antihypertensive agent. | ||||
| GC81584 | 2-Amino-2-deoxy-D-glucopyranose | 90-77-7 | >98.00% | |
2-Amino-2-deoxy-D-glucopyranose is an isomeric form of Glucosamine. | ||||
| GC81594 | TLSC702 | 748786-57-4 | >95.50% | |
TLSC702 is a human glyoxalase I ( hGLO I ) inhibitor with an IC 50 of 2.0 μM. | ||||
| GC81595 | BCS12 | 329719-71-3 | >99.50% | |
BCS12 is a CAIX inhibitor. | ||||
| GC81602 | Glucosamine sulfate potassium chloride | 1296149-08-0 | >98.00% | |
Glucosamine sulfate potassium chloride is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. | ||||
| GC81628 | Nicotinamide- 13 C, 15 N | - | >98.50% | |
Nicotinamide - 13 C, 15 N (Niacinamide- 13 C, 15 N) is the 13 C- and 15 N-labeled Nicotinamide. | ||||
| GC81637 | EBET-1593 | 3031540-97-0 | >98% | |
EBET-1593 is a BET PROTAC degrader. | ||||
| GC81639 | SH-26 | - | >98% | |
SH-26 is a PHD1 PROTAC degrader with DC 50 s of 1.06 μM, 4.16 μM and 4.91 μM in MDA-MB-231, HepG2 and HEK-293T cells, respectively. | ||||
| GC81658 | FAM-hsa-miR-147b-5p mimic | - | >98.00% | |
FAM-hsa-miR-147b-5p mimic is a FAM-labeled hsa-miR-147b-5p mimic. | ||||
| GC81659 | GAPDH Positive Control siRNA (Human) | - | >98.00% | |
GAPDH Positive Control siRNA (Human), a siRNA product, is a human GAPDH siRNA positive control. | ||||
| GC81660 | GAPDH siRNA Positive Control (Mouse/Rat) | - | >98.00% | |
GAPDH siRNA Positive Control (Mouse/Rat), a siRNA product, is a mouse/rat GAPDH siRNA positive control. | ||||
| GC81674 | MKI-3 | 3084702-28-0 | >98% | |
MKI-3 is a selective microtubule-associated serine/threonine kinase-like ( MASTL ) inhibitor with an IC 50 of 5.72 nM and a K d of 1.89 nM. | ||||
| GC81676 | Endosidin7 | 329072-88-0 | >98% | |
Endosidin7 is a specific inhibitor for plant callose deposition during cytokinesis. | ||||
| GC81685 | GDP-azido-fucose disodium | 944560-34-3 | >99.50% | |
GDP-azido-fucose disodium is a glycoengineering tool. | ||||
| GC81697 | SA91-0178 | 2244341-81-7 | >98.00% | |
SA91-0178 is a METTL1 inhibitor. | ||||
| GC81705 | (R)-I-BET762 carboxylic acid (Standard) | 1786401-70-4 | >98.00% | |
(R)-I-BET762 carboxylic acid (Standard) is the analytical standard of (R)-I-BET762 carboxylic acid. | ||||
| GC81720 | DDO3602 | - | >98% | |
DDO3602 is a PARP1 HSPTAC ( HSP90 -mediated proteolysis-targeting chimera) degrader, with a DC 50 of 490.3 nM against PARP1; its K d values for PARP1 and HSP90 are 66.5 nM and 1.64 nM, respectively. | ||||
| GC81758 | HDAC11-IN-5 | - | >98.00% | |
HDAC11-IN-5 is a selective, potent and orally active HDAC11 inhibitor with an IC 50 of 0.021 μM. | ||||
| GC81822 | 4-Chloro-N-methylpicolinamide-d₃ | 1189858-48-7 | >98.00% | |
4-Chloro-N-methylpicolinamide -d 3 is the deuterated-labeled 4-Chloro-N-methylpicolinamide. | ||||
| GC81837 | Histone H4 peptide substrate (1-21) acetate | - | >98.00% | |
Histone H4 peptide substrate (1-21) acetate is a PAD4 peptide substrate. | ||||
| GC81867 | Ac-ETDK(myr)-AMC acetate | - | >98.00% | |
Ac-ETDK(myr)-AMC acetate is a DLAT-derived ε-N-myristoyllysine peptide substrate for fatty-acid deacylase HDAC11, used in fluorescence-based HDAC11 activity assays. | ||||
| GC81872 | CPTH2-d₄ | - | >98% | |
CPTH2 -d 4 is the deuterated-labeled CPTH2. | ||||
| GC81879 | NCP26 TFA | - | >99.50% | |
NCP26 TFA is an ATP-competitive ProRS inhibitor (with a K D of 271 nM in the absence of proline, and a K D of 0.35 nM in the presence of 100 μM proline). | ||||