Pregnanediol-3-Glucuronide (Synonyms: Pregnanediol-3α-Glucuronide) |
| Catalog No.GC41266 |
Le prégnandiol-3-glucuronide est le principal métabolite terminal de la progestérone, jouant un rôle important dans les processus physiologiques, tels que le cycle menstruel féminin, la grossesse (soutient la gestation), l'embryogenèse et la réponse immunitaire maternelle des humains et d'autres espèces.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1852-49-9
Sample solution is provided at 25 µL, 10mM.
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Pregnanediol-3-glucuronide (PDG) is the primary urinary metabolite of the steroid hormone progesterone. [1] Levels of PDG in the urine correlate to levels of progesterone measured in the serum.[1] [2] Analysis of urinary PDG has been used to detect ovulatory and anovulatory menstrual cycles in women as well as to assess the fertility of ovulatory cycles.[3] [4]
Reference:
[1]. O'Connor, K.A., Brindle, E., Holman, D.J., et al. Urinary estrone conjugate and pregnanediol 3-glucuronide enzyme immunoassays for population research. Clin. Chem. 49(7), 1139-1148 (2003).
[2]. Munro, C.J., Stabenfeldt, G.H., Cragun, J.R., et al. Relationship of serum estradiol and progesterone concentrations to the excretion profiles of their major urinary metabolites as measured by enzyme immunoassay and radioimmunoassay. Clin. Chem. 37(6), 838-844 (1991).
[3]. Kassam, A., Overstreet, J.W., Snow-Harter, C., et al. Identification of anovulation and transient luteal function using a urinary pregnanediol-3-glucuronide ratio algorithm. Environ. Health Perspect. 104(4), 408-413 (1996).
[4]. Blackwell, L.F., Cooke, D.G., and Brown, S. The use of estrone-3-glucuronide and pregnanediol-3-Glucuronide Excretion Rates to Navigate the Continuum of Ovarian Activity. Front. Public Health 6:153, (2018).
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