RPH-2823 |
| Katalog-Nr.GC30414 |
RPH-2823, ein basisches Triamteren-Derivat, induziert eine dosisabhÄngige Abnahme des Kurzschlussstroms (SCC) und eine ErhÖhung des transepithelialen elektrischen Widerstands.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 96558-24-6
Sample solution is provided at 25 µL, 10mM.
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RPH-2823 is a basic triamterene derivative, with diuretic activity.
RPH 2823 induces a dose-dependent decrease in SCC and increase in transepithelial electrical resistance. RPH 2823 influences transepithelial Na+ transport by interacting with the Na+ channel or a regulator site of it within the apical membrane[1].
RPH 2823 (2.5 mumol/kg) can avoid the kaliuresis of 25 mumol/kg furosemide in male Wistar rats. RPH 2823 (1 mg/kg and 5 mg/kg, i.v.) has a terminal elimination half-life of 3 h. About 47% of the given dose are excreted unchanged with urine[2].
[1]. Kipnowski J, et al. Effects of standard diuretics and RPH 2823 on transepithelial Na+ transport in isolated frog skin. Klin Wochenschr. 1986 Aug 15;64(16):750-9. [2]. Priewer H, et al. Pharmacodynamics and pharmacokinetics of the basic triamterene analogue dimethylaminohydroxypropoxytriamterene. Arzneimittelforschung. 1985;35(11):1688-91.
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