SN-38 Glucuronide (Synonyms: SN-38G) |
| Catalog No.GC49760 |
Le SN-38 glucuronide est un métabolite inactif du médicament anticancéreux Irinotecan. L'irinotécan est un inhibiteur de la topoisomérase I qui peut être utilisé pour la recherche sur le cancer du cÔlon et du rectum.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 121080-63-5
Sample solution is provided at 25 µL, 10mM.
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SN-38 Glucuronide is a phase II metabolite of irinotecan .1 It is formed via glucuronidation of the irinotecan phase I metabolite SN-38 by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1.
1.Hirose, K., Kozu, C., Yamashita, K., et al.Correlation between plasma concentration ratios of SN-38 glucuronide and SN-38 and neutropenia induction in patients with colorectal cancer and wild-type UGT1A1 geneOncol. Lett.3(3)694-698(2012)
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