SN-38 Glucuronide (Synonyms: SN-38G) |
| Katalog-Nr.GC49760 |
SN-38-Glucuronid ist ein inaktiver Metabolit des Krebsmedikaments Irinotecan. Irinotecan ist ein Topoisomerase-I-Hemmer, der zur Erforschung von Dickdarm- und Enddarmkrebs eingesetzt werden kann.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 121080-63-5
Sample solution is provided at 25 µL, 10mM.
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SN-38 Glucuronide is a phase II metabolite of irinotecan .1 It is formed via glucuronidation of the irinotecan phase I metabolite SN-38 by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1.
1.Hirose, K., Kozu, C., Yamashita, K., et al.Correlation between plasma concentration ratios of SN-38 glucuronide and SN-38 and neutropenia induction in patients with colorectal cancer and wild-type UGT1A1 geneOncol. Lett.3(3)694-698(2012)
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