Spermine NONOate |
| Catalog No.GC13694 |
Le NONOate de spermine est un complexe d'oxyde nitrique (NO) avec de la spermine et agit comme un donneur de NO.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 136587-13-8
Sample solution is provided at 25 µL, 10mM.
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Spermine NONOate is a diazeniumdiolate nitric oxide donor [1].
Nitric oxide (NO) increases intracellular guanosine 3' 5' cyclic monophosphate and activates guanylate cyclase, which then cause relaxation of vascular smooth muscle [1].
Spermine NONOate is a diazeniumdiolate nitric oxide donor. In rat pulmonary artery rings, spermine NONOate (100 μM) increased guanosine 3'5' cyclic monophosphate (cyclic GMP) by 35 fold and caused cyclic GMP-independent relaxation by activation of sarco-endoplasmic reticulum Ca2+-ATPase, Na+/K+-ATPase and calcium-activated potassium channels [1]. Spermine NONOate inhibited human low-density lipoprotein (LDL) oxidation induced by the copper(II) sulfate [2].
In rats with bilateral uterine horn injury, spermine NONOate (1 mg) inhibited the formation of adhesions. Also, The N,O-carboxymethylchitosan (NOCC) plus spermine NONOate group had a lower severity score and extent score than the spermine NONOate group. These results suggested that spermine NONOate reduced the postoperative adhesions [3].
References:
[1]. Homer KL, Wanstall JC. Cyclic GMP-independent relaxation of rat pulmonary artery by spermine NONOate, a diazeniumdiolate nitric oxide donor. Br J Pharmacol, 2000, 131(4): 673-682.
[2]. Goss SP, Hogg N, Kalyanaraman B. The antioxidant effect of spermine NONOate in human low-density lipoprotein. Chem Res Toxicol, 1995, 8(5): 800-806.
[3]. Duran B, Ak D, Cetin A, et al. Reduction of postoperative adhesions by N,O-carboxymethylchitosan and spermine NONOate in rats. Exp Anim, 2003, 52(4): 267-272.
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