Syk Inhibitor II (Synonyms: Spleen Tyrosine Kinase Inhibitor II) |
| Catalog No.GC44978 |
L'inhibiteur de Syk II est un inhibiteur de Syk puissant, hautement sélectif et compétitif pour l'ATP avec une IC50 de 41 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 726695-51-8
Sample solution is provided at 25 µL, 10mM.
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Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs and mediates downstream signaling. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 µM, respectively). Syk inhibitor II has been shown to prevent FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and to inhibit passive cutaneous anaphylaxis reactions in mice (ID50 = 13.2 mg/kg, s.c.).
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