Syk Inhibitor II (Synonyms: Spleen Tyrosine Kinase Inhibitor II) |
| カタログ番号GC44978 |
Syk Inhibitor II は、41 nM の IC50 を持つ、強力で高選択的で ATP 競合性の Syk 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 726695-51-8
Sample solution is provided at 25 µL, 10mM.
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Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs and mediates downstream signaling. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 µM, respectively). Syk inhibitor II has been shown to prevent FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and to inhibit passive cutaneous anaphylaxis reactions in mice (ID50 = 13.2 mg/kg, s.c.).
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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