TCMDC-135051 |
| Catalog No.GC39162 |
TCMDC-135051 est un inhibiteur hautement sélectif et puissant de la protéine kinase PfCLK3 avec une faible toxicité hors cible.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2413716-15-9
Sample solution is provided at 25 µL, 10mM.
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TCMDC-135051 is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity. TCMDC-135051 prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 has antiparasiticidal activity (EC50=320 nM)[1].
[1]. Alam MM, et al. Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target. Science. 2019 Aug 30;365(6456). pii: eaau1682.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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