11-dehydro Thromboxane B2-d4 (Synonyms: 11-dehydro TXB2-d4, 11keto TXB2d4) |
カタログ番号GC46408
One-Click Copy Product Info
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11-デヒドロトロンボキサンB2の定量化のための内部標準
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1240398-15-5
Sample solution is provided at 25 µL, 10mM.
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11-dehydro Thromboxane B2-d4 (TXB2-d4) is intended for use as an internal standard for the quantification of 11-dehydro TXB2 by stable isotope dilution MS. TXB2 is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-
1.Ciabattoni, G., Pugliese, F., Davi, G., et al.Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in manBiochimica et Biophysica Acta99266-70(1989) 2.Fitzgerald, G.A., Lawson, J., Blair, I.A., et al.Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometryAdvances in Prostaglandin, Thromboxane, and Leukotriene Research1587-90(1985) 3.Takasaki, W., Nakagawa, A., Tanaka, Y., et al.Enzyme immunoassay of human plasma 11-dehydrothromboxane B2Thrombosis Research63331-341(1991) 4.Catella, F., Healy, D., Lawson, J.A., et al.11-dehydro Thromboxane B2: A quantitative index of thromboxane A2 formation in the human circulationProceedings of the National Academy of Sciences of the United States of America835861-5865(1986)
| Cas No. | 1240398-15-5 | SDF | |
| 同義語 | 11-dehydro TXB2-d4, 11keto TXB2d4 | ||
| Canonical SMILES | O[C@@H]1[C@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](/C=C/[C@H](O)CCCCC)OC(C1)=O | ||
| Formula | C20H28D4O6 | M.Wt | 372.5 |
| 溶解度 | DMF: >50 mg/ml (from TXB2),DMSO: >25 mg/ml (from TXB2),Ethanol: >100 mg/ml (from TXB2),PBS pH 7.2: >100 μg/ml (from TXB2) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6846 mL | 13.4228 mL | 26.8456 mL |
| 5 mM | 536.9 μL | 2.6846 mL | 5.3691 mL |
| 10 mM | 268.5 μL | 1.3423 mL | 2.6846 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solution in methyl acetate
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)