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2OH-BNPP1

カタログ番号GC34080

2OH-BNPP1 は、がんの治療に使用される Ser/Thr キナーゼである BUB1 キナーゼの阻害剤です。

Products are for research use only. Not for human use. We do not sell to patients.

2OH-BNPP1 化学構造

Cas No.: 833481-73-5

サイズ 価格 在庫数 個数
10mM (in 1mL DMSO)
$150.00
在庫あり
2mg
$92.00
在庫あり
5mg
$166.00
在庫あり
10mg
$295.00
在庫あり
25mg
$607.00
在庫あり
50mg
$1,011.00
在庫あり
100mg
$1,747.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description Protocol Chemical Properties Product Documents Related Products

2OH-BNPP1 is an inhibitor of BUB1 kinase, a Ser/Thr kinase, used for the treatment of cancer.

2OH-BNPP1 (0.1-50 μM) abrogates TGFβ signaling in a dose dependent manner. 2OH-BNPP1 dose-dependently impairs the TGFβ-induced phosphorylation of proteins that mediate canonical and non-canonical TGFβ signaling in multiple cancer cell lines and normal cell lines[1].

2OH-BNPP1 (50 mg/kg) blocks TGFβ signaling in vivo, and significantly decreases abundance of phosphorylated SMAD2 in tumor-bearing mice[1].

[1]. Nyati S, et al. The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling. Sci Signal. 2015 Jan 6;8(358):ra1.

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