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Immunology/Inflammation

The immune and inflammation-related pathway including the Toll-like receptors pathway, the B cell receptor signaling pathway, the T cell receptor signaling pathway, etc.

Toll-like receptors (TLRs) play a central role in host cell recognition and responses to microbial pathogens. TLR4 initially recruits TIRAP and MyD88. MyD88 then recruits IRAKs, TRAF6, and the TAK1 complex, leading to early-stage activation of NF-κB and MAP kinases [1]. TLR4 is endocytosed and delivered to intracellular vesicles and forms a complex with TRAM and TRIF, which then recruits TRAF3 and the protein kinases TBK1 and IKKi. TBK1 and IKKi catalyze the phosphorylation of IRF3, leading to the expression of type I IFN [2].

BCR signaling is initiated through ligation of mIg under conditions that induce phosphorylation of the ITAMs in CD79, leading to the activation of Syk. Once Syk is activated, the BCR signal is transmitted via a series of proteins associated with the adaptor protein B-cell linker (Blnk, SLP-65). Blnk binds CD79a via non-ITAM tyrosines and is phosphorylated by Syk. Phospho-Blnk acts as a scaffold for the assembly of the other components, including Bruton’s tyrosine kinase (Btk), Vav 1, and phospholipase C-gamma 2 (PLCγ2) [3]. Following the assembly of the BCR-signalosome, GRB2 binds and activates the Ras-guanine exchange factor SOS, which in turn activates the small GTPase RAS. The original RAS signal is transmitted and amplified through the mitogen-activated protein kinase (MAPK) pathway, which including the serine/threonine-specific protein kinase RAF followed by MEK and extracellular signal related kinases ERK 1 and 2 [4]. After stimulation of BCR, CD19 is phosphorylated by Lyn. Phosphorylated CD19 activates PI3K by binding to the p85 subunit of PI3K and produce phosphatidylinositol-3,4,5-trisphosphate (PIP3) from PIP2, and PIP3 transmits signals downstream [5].

Central process of T cells responding to specific antigens is the binding of the T-cell receptor (TCR) to specific peptides bound to the major histocompatibility complex which expressed on antigen-presenting cells (APCs). Once TCR connected with its ligand, the ζ-chain–associated protein kinase 70 molecules (Zap-70) are recruited to the TCR-CD3 site and activated, resulting in an initiation of several signaling cascades. Once stimulation, Zap-70 forms complexes with several molecules including SLP-76; and a sequential protein kinase cascade is initiated, consisting of MAP kinase kinase kinase (MAP3K), MAP kinase kinase (MAPKK), and MAP kinase (MAPK) [6]. Two MAPK kinases, MKK4 and MKK7, have been reported to be the primary activators of JNK. MKK3, MKK4, and MKK6 are activators of P38 MAP kinase [7]. MAP kinase pathways are major pathways induced by TCR stimulation, and they play a key role in T-cell responses.

Phosphoinositide 3-kinase (PI3K) binds to the cytosolic domain of CD28, leading to conversion of PIP2 to PIP3, activation of PKB (Akt) and phosphoinositide-dependent kinase 1 (PDK1), and subsequent signaling transduction [8].

 

References

[1] Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors[J]. Nature immunology, 2010, 11(5): 373-384.

[2] Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity[J]. Immunity, 2011, 34(5): 637-650.

[3] Packard T A, Cambier J C. B lymphocyte antigen receptor signaling: initiation, amplification, and regulation[J]. F1000Prime Rep, 2013, 5(40.10): 12703.

[4] Zhong Y, Byrd J C, Dubovsky J A. The B-cell receptor pathway: a critical component of healthy and malignant immune biology[C]//Seminars in hematology. WB Saunders, 2014, 51(3): 206-218.

[5] Baba Y, Matsumoto M, Kurosaki T. Calcium signaling in B cells: regulation of cytosolic Ca 2+ increase and its sensor molecules, STIM1 and STIM2[J]. Molecular immunology, 2014, 62(2): 339-343.

[6] Adachi K, Davis M M. T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells[J]. Proceedings of the National Academy of Sciences, 2011, 108(4): 1549-1554.

[7] Rincón M, Flavell R A, Davis R A. The Jnk and P38 MAP kinase signaling pathways in T cell–mediated immune responses[J]. Free Radical Biology and Medicine, 2000, 28(9): 1328-1337.

[8] Bashour K T, Gondarenko A, Chen H, et al. CD28 and CD3 have complementary roles in T-cell traction forces[J]. Proceedings of the National Academy of Sciences, 2014, 111(6): 2241-2246.

Products for  Immunology/Inflammation

  1. Cat.No. 商品名 インフォメーション
  2. GC50569 NLRP3-IN-2 グリブリド合成の中間基質である NLRP3-IN-2 は、心筋細胞における NLRP3 インフラマソームの形成を阻害し、マウスの心筋虚血/再灌流後の梗塞サイズを、グルコース代謝に影響を与えることなく制限します 。  NLRP3-IN-2  Chemical Structure
  3. GC45194 α-(difluoromethyl)-DL-Arginine

    Bacteria synthesize the cellular growth factor putrescine through a number of pathways.

    α-(difluoromethyl)-DL-Arginine  Chemical Structure
  4. GC65446 α-Amyrin acetate α-天然のトリテルペノイドである酢酸アミリンには、抗炎症作用、鎮痙作用、および弛緩作用があります。 α-Amyrin acetate  Chemical Structure
  5. GC48279 α-D-Glucose-1-phosphate (sodium salt hydrate) An intermediate in glycogen metabolism α-D-Glucose-1-phosphate (sodium salt hydrate)  Chemical Structure
  6. GC45206 α-GalCer analog 8

    α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide.

    α-GalCer analog 8  Chemical Structure
  7. GC40262 α-Humulene α- フムレンはタナセタム・ブルガレ L の主成分です。 α-Humulene  Chemical Structure
  8. GC45601 α-Linolenic Acid ethyl ester-d5   α-Linolenic Acid ethyl ester-d5  Chemical Structure
  9. GC48292 α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) α-MSH (α-メラノサイト刺激ホルモン) 内因性神経ペプチドである TFA は、抗炎症作用と解熱作用を持つ内因性メラノコルチン受容体 4 (MC4R) アゴニストです。 α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)  Chemical Structure
  10. GC41499 α-Phellandrene α-Phellandrene is a cyclic monoterpene that has been found in various plants, including Cannabis, and has diverse biological activities. α-Phellandrene  Chemical Structure
  11. GC63941 α-Solanine α- 生物活性成分であり、ジャガイモに含まれる主要なステロイド性グリコアルカロイドの 1 つであるソラニンは、がん細胞の成長を阻害し、アポトーシスを誘導することが観察されています。 α-Solanine  Chemical Structure
  12. GC49467 β-Aescin A triterpenoid saponin with diverse biological activities β-Aescin  Chemical Structure
  13. GC37999 β-Anhydroicaritin β-アンヒドロイカリチンはボスウェリア カルテリ バードウェアから分離され、抗骨粗鬆症、エストロゲン調節、抗腫瘍特性などの重要な生物学的および薬理学的効果があります。 β-Anhydroicaritin  Chemical Structure
  14. GC45225 β-Apooxytetracycline β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. β-Apooxytetracycline  Chemical Structure
  15. GC48920 β-Carboline-1-carboxylic Acid An alkaloid with diverse biological activities β-Carboline-1-carboxylic Acid  Chemical Structure
  16. GC48998 β-Defensin-1 (human) (trifluoroacetate salt) An antimicrobial peptide β-Defensin-1 (human) (trifluoroacetate salt)  Chemical Structure
  17. GC48298 β-Defensin-2 (human) (trifluoroacetate salt) An antimicrobial peptide β-Defensin-2 (human) (trifluoroacetate salt)  Chemical Structure
  18. GC45230 β-Defensin-3 (human) (trifluoroacetate salt) β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. β-Defensin-3 (human) (trifluoroacetate salt)  Chemical Structure
  19. GC45231 β-Defensin-4 (human) (trifluoroacetate salt) β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. β-Defensin-4 (human) (trifluoroacetate salt)  Chemical Structure
  20. GC41623 β-Elemonic Acid β-エレモン酸は、ボスウェリア パピリフェラから分離されたトリテルペンです。 β-Elemonic Acid  Chemical Structure
  21. GC64619 β-Ionone β-イオノンは、胃腺癌 SGC7901 細胞のアポトーシスの誘導に効果的です。抗がん作用。 β-Ionone  Chemical Structure
  22. GC41502 β-Myrcene β-ミルセン (β-β-ミルセン)、芳香族揮発性化合物は、TNFα 誘導 NF-κB 活性を抑制します。 β-Myrcene  Chemical Structure
  23. GC45604 β-Rubromycin β-ルブロマイシンは、ヒト免疫不全ウイルス 1 (HIV-1) RNA 指向 DNA ポリメラーゼ (逆転写酵素) の強力かつ選択的な阻害剤です。 β-Rubromycin  Chemical Structure
  24. GC48312 γ-Glu-Cys (ammonium salt) An intermediate in GSH synthesis γ-Glu-Cys (ammonium salt)  Chemical Structure
  25. GC40790 γ-Linolenic Acid ethyl ester γ-Linolenic acid (GLA) is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. γ-Linolenic Acid ethyl ester  Chemical Structure
  26. GC45238 δ14-Triamcinolone acetonide δ14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide. δ14-Triamcinolone acetonide  Chemical Structure
  27. GC40307 δ2-cis-Hexadecenoic Acid One of the first organisms in which quorum sensing was observed were Myxobacteria, a group of gram-negative bacteria, found mainly in soil and also common to marine and freshwater systems. δ2-cis-Hexadecenoic Acid  Chemical Structure
  28. GC41393 ω-3 Arachidonic Acid methyl ester ω-3 Fatty acids, represented primarily by docosahexaenoic acid, eicosapentaenoic acid, and α-linoleate, are essential dietary nutrients required for normal growth and development. ω-3 Arachidonic Acid methyl ester  Chemical Structure
  29. GC45713 (±)-α-Tocopherol Acetate (±)-α-酢酸トコフェロール ((±)-ビタミン E アセテート) は、ビタミン E の経口活性合成形態です。 (±)-α-Tocopherol Acetate  Chemical Structure
  30. GC52010 (±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic Acid An oxylipin gut microbiota metabolite (±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic Acid  Chemical Structure
  31. GC52013 (±)-10-hydroxy-12(Z)-Octadecenoic Acid An oxylipin and metabolite of linoleic acid (±)-10-hydroxy-12(Z)-Octadecenoic Acid  Chemical Structure
  32. GC40112 (±)-Climbazole-d4 (±)-Climbazole-d4 is intended for use as an internal standard for the quantification of climbazole by GC- or LC-MS. (±)-Climbazole-d4  Chemical Structure
  33. GC50708 (±)-ML 209 An RORγt antagonist (±)-ML 209  Chemical Structure
  34. GC39271 (±)-Naringenin (±)-ナリンゲニンは天然のフラボノイドです。 (±)-Naringenin  Chemical Structure
  35. GC41212 (±)10(11)-EpDPA Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA  Chemical Structure
  36. GC40466 (±)11(12)-EET (±)11(12)-EET は NLRP3 インフラマソーム阻害剤です。 (±)11(12)-EET  Chemical Structure
  37. GC40467 (±)11-HETE (±)11-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. (±)11-HETE  Chemical Structure
  38. GC40802 (±)12(13)-DiHOME

    (±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin.

    (±)12(13)-DiHOME  Chemical Structure
  39. GC41191 (±)13(14)-EpDPA (±)13(14)-EpDPA (13,14-EpDPE) は、シトクロム P-450 エポキシゲナーゼとドコサヘキサエン酸 (DHA) の反応生成物です。 (±)13(14)-EpDPA  Chemical Structure
  40. GC40355 (±)13-HpODE (±)13-HpODE (13-ヒドロペルオキシリノール酸) は、リポキシゲナーゼによるリノール酸の酸化によって生成されるヒドロペルオキシドのラセミ混合物です。 (±)13-HpODE  Chemical Structure
  41. GC41288 (±)17(18)-EpETE-Ethanolamide (±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide. (±)17(18)-EpETE-Ethanolamide  Chemical Structure
  42. GC40362 (±)18-HEPE (±)18-HEPE is produced by non-enzymatic oxidation of EPA. (±)18-HEPE  Chemical Structure
  43. GC41655 (±)19(20)-EDP Ethanolamide (±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). (±)19(20)-EDP Ethanolamide  Chemical Structure
  44. GC40270 (±)5(6)-DiHET

    5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET by epoxide hydrolases.

    (±)5(6)-DiHET  Chemical Structure
  45. GC41203 (±)7(8)-EpDPA Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA  Chemical Structure
  46. GC40801 (±)9(10)-DiHOME (±)9(10)-DiHOME は 9,10-DiHOME のラセミ体です。 (±)9(10)-DiHOME  Chemical Structure
  47. GC46000 (•)-Drimenol A sesquiterpene alcohol (•)-Drimenol  Chemical Structure
  48. GC40809 (+)-β-Citronellol (+)-β-シトロネロール (D-シトロネロール) は、ゼラニウム エッセンシャル オイルに含まれるアルコール性モノテルペンです。 (+)-β-Citronellol  Chemical Structure
  49. GC49268 (+)-δ-Cadinene A sesquiterpene with antimicrobial and anticancer activities (+)-δ-Cadinene  Chemical Structure
  50. GN10654 (+)-Corynoline Extracted from corydalis sheareri S. Moore;Store the product in sealed,cool and dry condition (+)-Corynoline  Chemical Structure
  51. GC45263 (+)-D-threo-PDMP (hydrochloride) (+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP. (+)-D-threo-PDMP (hydrochloride)  Chemical Structure
  52. GC31691 (+)-DHMEQ (+)-DHMEQ は、抗酸化転写因子 Nrf2 の活性化因子です。 (+)-DHMEQ  Chemical Structure
  53. GC45266 (+)-Macrosphelide A (+)-マクロフェライド A はマクロライド系抗生物質です。 (+)-Macrosphelide A  Chemical Structure
  54. GC40266 (+)-Praeruptorin A (+)-Praeruptorin A は、Peucedanum praeruptorum (Bai-Hua Qian Hu としても知られています) の主要な生理活性成分です。 (+)-Praeruptorin A  Chemical Structure
  55. GC18749 (+)-Rugulosin (+)-ルグロシンは、ペニシリウム ルグロサム トムの結晶色素です。 (+)-Rugulosin  Chemical Structure
  56. GC63969 (+)-Schisandrin B (+)-シサンドリン B は、シサンドリン B のエナンチオマーです。 (+)-Schisandrin B  Chemical Structure
  57. GC40264 (+)-Valencene

    (+)-Valencene is a sesquiterpene that has been found in C.

    (+)-Valencene  Chemical Structure
  58. GC49502 (-)-β-Sesquiphellandrene A sesquiterpene with antiviral and anticancer activities (-)-β-Sesquiphellandrene  Chemical Structure
  59. GC32705 (-)-DHMEQ (Dehydroxymethylepoxyquinomicin) (-)-DHMEQ (デヒドロキシメチルエポキシキノマイシン) (デヒドロキシメチルエポキシキノマイシン) は、システイン残基に共有結合する強力で選択的かつ不可逆的な NF-κB 阻害剤です。 (-)-DHMEQ (Dehydroxymethylepoxyquinomicin)  Chemical Structure
  60. GC14049 (-)-Epigallocatechin gallate (EGCG) (-)-エピガロカテキンガレート (EGCG) (EGCG) は、緑茶に含まれる主要なポリフェノールであり、細胞増殖を阻害し、細胞アポトーシスを誘導することができます。 (-)-Epigallocatechin gallate (EGCG)  Chemical Structure
  61. GC45248 (-)-FINO2 (-)-FINO2 は強力なフェロトーシス誘導因子です。 (-)-FINO2 は GPX4 活性を阻害します。 (-)-FINO2 は、第一鉄を酸化する安定した酸化剤であり、さまざまな pH レベルで安定しています。 (-)-FINO2 は広範な脂質過酸化を引き起こします。 (-)-FINO2  Chemical Structure
  62. GC46245 (-)-G-Lactone A bicyclic γ-lactone (-)-G-Lactone  Chemical Structure
  63. GC38316 (-)-Limonene (-)-リモネン ((S)-(-)-リモネン) は、多くの松葉油やテレビン油に含まれるモノテルペンです。 (-)-Limonene  Chemical Structure
  64. GC46247 (-)-Mycousnine A microbial metabolite with antibacterial and antifungal activities (-)-Mycousnine  Chemical Structure
  65. GC45251 (-)-Neplanocin A S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. (-)-Neplanocin A  Chemical Structure
  66. GC45272 (-)-Rasfonin (-)-ラスフォニンは真菌の二次代謝産物であり、小さな G タンパク質である Ras を阻害します。 (-)-ラスフォニンは、ACHN 細胞 (腎癌細胞株) のアポトーシス、壊死、およびオートファジーを誘導します。 (-)-Rasfonin  Chemical Structure
  67. GC40803 (25S)-δ7-Dafachronic Acid During unfavorable environmental conditions, C. (25S)-δ7-Dafachronic Acid  Chemical Structure
  68. GC41700 (E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities. (E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine  Chemical Structure
  69. GC61668 (E)-3,4-Dimethoxycinnamic acid (E)-3,4-ジメトキシ桂皮酸は、3,4-ジメトキシ桂皮酸の活性の低い異性体です。 (E)-3,4-Dimethoxycinnamic acid  Chemical Structure
  70. GC41702 (E)-5-(2-Bromovinyl)uracil (E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. (E)-5-(2-Bromovinyl)uracil  Chemical Structure
  71. GC49003 (E)-Ajoene A disulfide with diverse biological activities (E)-Ajoene  Chemical Structure
  72. GC41703 (E)-C-HDMAPP (ammonium salt) Synthetic and natural alkyl phosphates, also known as phosphoantigens, stimulate the proliferation of γδ-T lymphocytes. (E)-C-HDMAPP (ammonium salt)  Chemical Structure
  73. GC39747 (E/Z)-GSK5182 (E/Z)-GSK5182 は、(E)-GSK5182 および (Z)-GSK5182 異性体のラセミ化合物です。 (E/Z)-GSK5182  Chemical Structure
  74. GC61564 (E/Z)-IT-603 (E/Z)-IT-603 は、E-IT-603 と Z-IT-603 (IT-603) の混合物です。 (E/Z)-IT-603  Chemical Structure
  75. GC41721 (R)-α-Lipoic Acid (R)-α-Lipoic acid is the naturally occurring enantiomer of lipoic acid, a cyclic disulfide antioxidant. (R)-α-Lipoic Acid  Chemical Structure
  76. GC49167 (R)-(+)-Trityl glycidyl ether A synthetic precursor (R)-(+)-Trityl glycidyl ether  Chemical Structure
  77. GC13030 (R)-(-)-Ibuprofen (R)-(-)-イブプロフェンはイブプロフェンのRエナンチオマーで、COXに対して不活性で、NF-κBの活性化を阻害します。 (R)-(-)-イブプロフェンは、抗炎症作用と抗侵害受容作用を示します。 (R)-(-)-Ibuprofen  Chemical Structure
  78. GC41620 (R)-(-)-Mellein (R)-(-)-メレインは、この麹菌の培養液から分離された抗生物質です。 (R)-(-)-Mellein  Chemical Structure
  79. GC41712 (R)-3-hydroxy Myristic Acid Lipopolysaccharides (LPS) are components of the cell walls of Gram-negative bacteria. (R)-3-hydroxy Myristic Acid  Chemical Structure
  80. GC65610 (R)-5-Hydroxy-1,7-diphenyl-3-heptanone (R)-5-ヒドロキシ-1,7-ジフェニル-3-ヘプタノンは、ゲットウに見られるジアリールヘプタノイドです。 (R)-5-Hydroxy-1,7-diphenyl-3-heptanone  Chemical Structure
  81. GC65373 (R)-IL-17 modulator 4 (R)-IL-17 モジュレーター 4 は、IL-17 モジュレーター 4 の R 構成です。 (R)-IL-17 modulator 4  Chemical Structure
  82. GC12578 (R)-Lisofylline (R)-リソフィリン ((R)-リソフィリン) は、抗炎症特性を持つペントキシフィリンの代謝産物の (R)-エナンチオマーです。 (R)-Lisofylline  Chemical Structure
  83. GC52185 (R,S)-Anatabine-d4 (R,S)-Anatabine-d4  Chemical Structure
  84. GC39321 (Rac)-Myrislignan (Rac)-ミリスリグナンは、ミリスリグナンのラセミ体です。 (Rac)-Myrislignan  Chemical Structure
  85. GC46345 (S)-(-)-Perillaldehyde (S)-(-)-ペリルアルデヒドは、シソに含まれる精油の主要成分です。 (S)-(-)-Perillaldehyde  Chemical Structure
  86. GC49028 (S)-3-Thienylglycine A thienyl-containing amino acid (S)-3-Thienylglycine  Chemical Structure
  87. GC52192 (S)-4'-nitro-Blebbistatin (S)-4'-ニトロ-ブレビスタチンは、非細胞毒性、光安定性、蛍光性の特異的ミオシン II 阻害剤であり、生理学的、発達的、および細胞生物学的研究におけるミオシン II の特定の役割の研究に使用されます。 (S)-4'-nitro-Blebbistatin  Chemical Structure
  88. GC48719 (S)-Canadine (S)-カナジンはアルカロイドであり、殺虫活性を持つベルベリンの生合成における中間体です。 (S)-Canadine  Chemical Structure
  89. GC46352 (S)-DO271 An inactive control for DO264 (S)-DO271  Chemical Structure
  90. GC11867 (S)-Lisofylline inactive optical enantiomer of (R)-LSF, an anti-inflammatory agent (S)-Lisofylline  Chemical Structure
  91. GC13427 (S)-Methylisothiourea sulfate (S)-メチルイソチオ尿素硫酸塩は、誘導型一酸化窒素合成酵素 (iNOS) の強力な選択的競合阻害剤です。 (S)-Methylisothiourea sulfate  Chemical Structure
  92. GC41740 (S)-p38 MAPK Inhibitor III (S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro). (S)-p38 MAPK Inhibitor III  Chemical Structure
  93. GC46356 (Z)-9-Hexadecenol An unsaturated long-chain fatty alcohol with diverse biological activities (Z)-9-Hexadecenol  Chemical Structure
  94. GC38880 (Z)-Leukadherin-1 (Z)-ロイカドヘリン-1 (ADH-503 遊離塩基) は、経口で活性なアロステリック CD11b アゴニストです。 (Z)-ロイカドヘリン-1 は、腫瘍関連マクロファージの再分極、腫瘍浸潤性免疫抑制性骨髄細胞の数の減少をもたらし、樹状細胞応答を増強します。 (Z)-Leukadherin-1  Chemical Structure
  95. GC18787 (±)-Dunnione (±)-Dunnione is a naturally occurring naphthoquinone with diverse biological activities. (±)-Dunnione  Chemical Structure
  96. GC13662 (±)-Lisofylline (±)-リソフィリン ((±)-リソフィリン) は、リソフィリンのラセミ体です。 (±)-Lisofylline  Chemical Structure
  97. GC46054 1β-Acetoxypolygodial A sesquiterpenoid 1β-Acetoxypolygodial  Chemical Structure
  98. GC45285 1,2,3-Trihexanoyl-rac-glycerol   1,2,3-Trihexanoyl-rac-glycerol  Chemical Structure
  99. GC46042 1,2-Dipalmitoyl-13C-sn-glycero-3-PC An internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PC 1,2-Dipalmitoyl-13C-sn-glycero-3-PC  Chemical Structure
  100. GC45781 1,2-Dipalmitoyl-d31-sn-glycero-3-PC An internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PC 1,2-Dipalmitoyl-d31-sn-glycero-3-PC  Chemical Structure
  101. GC46385 1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-α-D-Mannopyranose A ManNAc analog and building block 1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-α-D-Mannopyranose  Chemical Structure

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