4-(2,2,3-Trimethylcyclopentyl)butanoic Acid (Synonyms: GIV3727) |
カタログ番号GC42318
One-Click Copy Product Info
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4-(2,2,3-トリメチルシクロペンチル)ブタン酸は、人間の苦い味受容体hTAS2R31およびhTAS2R43のオルソステリックで不可逆的な拮抗剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 957136-80-0
Sample solution is provided at 25 µL, 10mM.
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4-(2,2,3-Trimethylcyclopentyl)butanoic acid is an orthosteric, insurmountable antagonist of the human bitter taste receptors hTAS2R31 and hTAS2R43. [1] It prevents the activation of hTAS2R31 by saccharin and acesulfame K in cells with IC50 values of 7.9 and 2.4 µM, respectively. [1] In human sensory trials, 4-(2,2,3-trimethylcyclopentyl)butanoic acid significantly reduced the bitter flavor associated with these two artificial sweeteners.[1]
Reference:
[1]. Slack, J.P., Brockhoff, A., Batram, C., et al. Modulation of bitter taste perception by a small molecule hTAS2R antagonist. Curr. Biol. 20(12), 1104-1109 (2010).
| Cas No. | 957136-80-0 | SDF | |
| 同義語 | GIV3727 | ||
| Chemical Name | 2,2,3-trimethyl-cyclopentanebutanoic acid | ||
| Canonical SMILES | OC(CCCC1CCC(C)C1(C)C)=O | ||
| Formula | C12H22O2 | M.Wt | 198.3 |
| 溶解度 | 25mg/mL in DMSO, 30mg/mL in DMF, 20mg/mL in Ethanol | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.0429 mL | 25.2143 mL | 50.4286 mL |
| 5 mM | 1.0086 mL | 5.0429 mL | 10.0857 mL |
| 10 mM | 504.3 μL | 2.5214 mL | 5.0429 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solution in methanol
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)