4-(2,2,3-Trimethylcyclopentyl)butanoic Acid (Synonyms: GIV3727) |
| Catalog No.GC42318 |
4-(2,2,3-Trimethylcyclopentyl)butanoic acid is an orthosteric, insurmountable antagonist of the human bitter taste receptors hTAS2R31 and hTAS2R43.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 957136-80-0
Sample solution is provided at 25 µL, 10mM.
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4-(2,2,3-Trimethylcyclopentyl)butanoic acid is an orthosteric, insurmountable antagonist of the human bitter taste receptors hTAS2R31 and hTAS2R43. [1] It prevents the activation of hTAS2R31 by saccharin and acesulfame K in cells with IC50 values of 7.9 and 2.4 µM, respectively. [1] In human sensory trials, 4-(2,2,3-trimethylcyclopentyl)butanoic acid significantly reduced the bitter flavor associated with these two artificial sweeteners.[1]
Reference:
[1]. Slack, J.P., Brockhoff, A., Batram, C., et al. Modulation of bitter taste perception by a small molecule hTAS2R antagonist. Curr. Biol. 20(12), 1104-1109 (2010).
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