4,6-Dioxoheptanoic acid (Synonyms: NSC 174804) |
| カタログ番号GC32483 |
4,6-ジオキソヘプタン酸は、ヘム生合成の強力な阻害剤です。
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Cas No.: 51568-18-4
Sample solution is provided at 25 µL, 10mM.
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4,6-Dioxoheptanoic acid is a potent inhibitor of heme biosynthesis.
4,6-Dioxoheptanoic acid (Succinylacetone, SA) is examined with regard to its ability to a) inhibit the second enzyme of the heme pathway, δ-aminolevulinic acid (ALA) dehydratase, b) lower the heme concentration, and c) inhibit cell growth of murine erythroleukemia (MEL) cells in culture[1].
[1]. Ebert PS, et al. Succinylacetone, a potent inhibitor of heme biosynthesis: effect on cell growth, heme contentand delta-aminolevulinic acid dehydratase activity of malignant murine erythroleukemia cells. Biochem Biophys Res Commun. 1979 Jun 27;88(4):1382-90.
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