(4-Acetamidocyclohexyl) nitrate (BM121307) (Synonyms: BM121307) |
| カタログ番号GC34045 |
(4-アセトアミドシクロヘキシル) ニトレート (BM121307) (BM121307) は、グアニル酸シクラーゼ活性化剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 137213-91-3
Sample solution is provided at 25 µL, 10mM.
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BM121307 is a guanylate cyclase activator that was in phase I development for the treatment of ischaemic heart disorders. The research has been discontinued.
The elimination of BM121307 and its metabolites via urine and feces amount to 76.5% after oral application, and to 80.7% of the applied dose after intravenous application. The major amount of radioactivity is eliminated via urine (69.4% and 73.6% of the dose, respectively), whereas the fecal elimination is found to be negligible. Investigations of the urinary samples show that the drug is metabolized to a high percentage trans-N-(4-Hydroxycyclohexyl) acetamide is the main metabolite; 73% of the radioactive compounds (after p.o.-administration and 69% after intravenous application could be identified as the alcohol of BM121307; the amounts of the drug totaled 9% and 13%, respectively[1].
[1]. Zell C, et al. Biotransformation of the organic nitrate trans-N-(4-nitroxycyclohexyl)acetamide in dogs. Arzneimittelforschung. 1994 Sep;44(9):1021-8.
Average Rating: 5 (Based on Reviews and 13 reference(s) in Google Scholar.)
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