4-Ethynyl-L-phenylalanine hydrochloride (Synonyms: 4-Ethynyl-L-phenylalanine hydrochloride) |
| カタログ番号GC60516 |
4-エチニル-L-フェニルアラニン塩酸塩（4-Ethynyl-L-phenylalanine hydrochloride）は、トリプトファンヒドロキシラーゼ（TPH）の強力で選択的な可逆的競合阻害剤であり、Ki値は32.6μMです。
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Cas No.: 188640-63-3
Sample solution is provided at 25 µL, 10mM.
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4-Ethynyl-L-phenylalanine hydrochloride is a selective, reversible, potent and competitive inhibitor of tryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine hydrochloride is a competitive inhibitor with regard to the substrate tryptophan, with a Ki of 32.6 μM. 4-Ethynyl-L-phenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin[1].
4-Ethynyl-L-phenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].4-Ethynyl-L-phenylalanine hydrochloride is not inhibiting the aromatic amino acid decarboxylase[1].4-Ethynyl-L-phenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors[1]. Animal Model: Male Sprague-Dawley rats (200 g)[1]
[1]. Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73.
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