4-Ethynyl-L-phenylalanine hydrochloride (Synonyms: 4-Ethynyl-L-phenylalanine hydrochloride) |
| カタログ番号GC60516 |
4-エチニル-L-フェニルアラニン塩酸塩（4-Ethynyl-L-phenylalanine hydrochloride）は、トリプトファンヒドロキシラーゼ（TPH）の強力で選択的な可逆的競合阻害剤であり、Ki値は32.6μMです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 188640-63-3
Sample solution is provided at 25 µL, 10mM.
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4-Ethynyl-L-phenylalanine hydrochloride is a selective, reversible, potent and competitive inhibitor of tryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine hydrochloride is a competitive inhibitor with regard to the substrate tryptophan, with a Ki of 32.6 μM. 4-Ethynyl-L-phenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin[1].
4-Ethynyl-L-phenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].4-Ethynyl-L-phenylalanine hydrochloride is not inhibiting the aromatic amino acid decarboxylase[1].4-Ethynyl-L-phenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors[1]. Animal Model: Male Sprague-Dawley rats (200 g)[1]
[1]. Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73.
| Cas No. | 188640-63-3 | SDF | |
| 同義語 | 4-Ethynyl-L-phenylalanine hydrochloride | ||
| Canonical SMILES | N[C@@H](CC1=CC=C(C#C)C=C1)C(O)=O.[H]Cl | ||
| Formula | C11H12ClNO2 | M.Wt | 225.67 |
| 溶解度 | Methanol: 125 mg/mL (553.91 mM); DMSO: 100 mg/mL (443.12 mM); Water: < 0.1 mg/mL (insoluble) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.4312 mL | 22.1562 mL | 44.3125 mL |
| 5 mM | 0.8862 mL | 4.4312 mL | 8.8625 mL |
| 10 mM | 0.4431 mL | 2.2156 mL | 4.4312 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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