4'-Acetyl Chrysomycin A |
カタログ番号GC48437 |
抗菌および抗がん活性を持つ細菌代謝産物
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Sample solution is provided at 25 µL, 10mM.
4'-Acetyl chrysomycin A is a bacterial metabolite and derivative of chrysomycin A that has been found in Streptomyces and has antibacterial and anticancer activities.1 It is active against strains of methicillin-resistant S. aureus (MRSA) and vancomycin-resistant strains of E. faecalis and E. faecium (MICs = 0.5-2 µg/ml for all). 4'-Acetyl chrysomycin A is cytotoxic against a panel of human cancer cell lines, including doxorubicin-sensitive or -resistant cells (IC50s = 0.085-0.26 and 3.4-16 ng/ml, respectively).
1.Wada, S.-I., Sawa, R., Iwanami, F., et al.Structures and biological activities of novel 4'-acetylated analogs of chrysomycins A and BJ. Antibiot. (Tokyo)70(11)1078-1082(2017)
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