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β-Defensin-1 (human) (trifluoroacetate salt) (Synonyms: hBD-1)

カタログ番号GC48998

抗菌ペプチド

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β-Defensin-1 (human) (trifluoroacetate salt) 化学構造

Cas No.: N/A

サイズ 価格 在庫数 個数
100 µg
$512.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

β-デフェンシン-1は、呼吸器、泌尿生殖器、および消化管の皮膚や粘膜を保護する抗菌性ペプチドです。1 抗菌放射拡散アッセイにおいて、B. adolescentisL. acidophilusB. breveB. vulgatusL. fermentum < em > B。longum および < em > S。thermophilus の成長を阻害します。2β-デフェンシン-1はまた口腔病原性および虫歯原性細菌(P。gingivalis およびS。salivarius)の成長を阻害し ますが,感受性のあるM.tuberculosis H37Rv では128μg/ml濃度で使用された場合に限り,耐性M.tuberculosis RM22 の成長を阻害しません。3,4 β-デフェンシン-1は、ヒトおよびマウスのKv1.3電位依存性カリウムチャネルをブロックします(IC50値=それぞれ11.8および13.2μM)。 5 HSC-3、UM-1、およびSCC-9という人間の口腔扁平上皮癌(OSCC)細胞株でβ-デフェンシン-1を過剰発現させると、増殖は増加しませんが移動性や浸潤性が増加します。

1. Lehrer, R.I. プライメート?ディフェンシンズ。Nat. Rev. Microbiol. 2(9)727-738 (2004) 2. Schroeder, B.O., Ehmann, D., Precht, J.C., et al.Paneth細胞α-defensin 6(HD-6)は抗菌ペプチドである。Mucosal Immunol.8(3)661-671(2015) 3. Ouhara、K。,Komatsuzawa、H。,Yamada、S。,et al.Periodontopathogenicおよびcariogenic bacteriaの人間上皮細胞によって生成された抗菌ペプチドβ-defensinsおよびLL37の感受性J.Antimicrob.Chemother。55(6)888-896(2005) 4.Fattorini、L。,Gennaro、R。,Zanetti、M。,et al.In vitro活性protegrin -1とbeta-defensin -1単独およびisoniazidと組み合わせてMycobacterium tuberculosis Peptides25(7)1075-1077 (2004) 5.Feng,J.,Xie,Z.,Yang,W.,et al.Human beta-defensin 1は新しい動物毒素様カリウムチャネルブロッカーですToxicon113(2016) 6.Han,Q.,Wang,R.,Sun,C.などHuman beta-defensin -1は腫瘍の移動と浸潤を抑制し、口腔扁平上皮癌患者の生存率の独立した予測因子であるPLoS One9(3)e91867(2014)

Chemical Properties

Cas No. N/A SDF
同義語 hBD-1
Canonical SMILES [H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(NCC(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCCN)C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CCC(N)=O)C(NCC(N[C@]([C@@H](C)O)([H])C2=O)=O)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)CSSC[C@H](N4)C(N[C@@H](CCCCN)C(O)=O)=O)=O)C)=O)=O)CC5=CC=C(O)C=C5)=O)=O)CSSC[C@H](N2)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCCN)C6=O)=O)C)=O)=O)=O)=O)CC7=CC=C(O)C=C7)=O)=O)=O)=O)=O)=O)=O)=O)CSSC[C@H](N6)C4=O)=O)=O)CC8=CC=C(O)C=C8)=O)CC9=CN=CN9)=O)CC(O)=O.FC(F)(C(O)=O)F
Formula C167H256N48O50S6·XCF3COOH M.Wt 3928.5
溶解度 Water: 1 mg/ml Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.
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計算

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Review for β-Defensin-1 (human) (trifluoroacetate salt)

Average Rating: 5 ★★★★★ (Based on Reviews and 40 reference(s) in Google Scholar.)

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