Aldosterone (Synonyms: 18-Aldocorticosterone, NSC 73856, Reichstein X) |
| カタログ番号GC41390 |
ステロイドホルモン
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Cas No.: 52-39-1
Sample solution is provided at 25 µL, 10mM.
Aldosterone is a steroid hormone secreted by the adrenal cortex and is the principle mineralocorticoid controlling sodium and potassium balance.[1],[2] Its primary role is to promote unidirectional salt reabsorption in epithelial tissues. Aldosterone is synthesized from cholesterol in the zona glomerulosa of the adrenal cortex and its secretion is regulated via the renin-angiotensin system.[3]
Reference:
[1]. Agarwal, M.K., and Mirshahi, M. General overview of mineralocorticoid hormone action. Pharmacology & Toxicology 84, 273-326 (1999).
[2]. Rogerson, F.M., and Fuller, P.J. Mineralocorticoid action. Steroids 65, 61-73 (2000).
[3]. Lumbers, E.R. Angiotensin and aldosterone. Regulatory Peptides 80, 91-100 (1999).
| Cas No. | 52-39-1 | SDF | |
| 同義語 | 18-Aldocorticosterone, NSC 73856, Reichstein X | ||
| Chemical Name | 11β,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al | ||
| Canonical SMILES | O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C([H])=O)[C@@]3([H])CC[C@@H]4C(CO)=O)=C1 | ||
| Formula | C21H28O5 | M.Wt | 360.4 |
| 溶解度 | 30mg/mL in DMSO, 30mg/ml in ethanol, 30mg/ml in DMF | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.7747 mL | 13.8735 mL | 27.7469 mL |
| 5 mM | 554.9 μL | 2.7747 mL | 5.5494 mL |
| 10 mM | 277.5 μL | 1.3873 mL | 2.7747 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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