all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid) (Synonyms: all-trans-4-keto Retinoic Acid, all-trans-4-oxo RA, all-trans-4-oxo Retinoic Acid, 4-keto atRA, 4-oxo RA) |
| カタログ番号GC31420 |
ビタミン A の活性代謝物であるオールトランス 4-オキソレチノイン酸 (オールトランス 4-ケトレチノイン酸) は、核レチノイン酸受容体 (RAR) への結合を介して遺伝子転写を誘導します。
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Cas No.: 38030-57-8
Sample solution is provided at 25 µL, 10mM.
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all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).
all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs)[1]. all-trans-4-Oxoretinoic acid is a biologically active geometric isomer of retinoic acid (RA) [2].
[1]. Topletz AR, et al. Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids. Mol Pharmacol. 2015;87(3):430-41. [2]. Stahl W, et al. 4-oxo-retinoic acid is generated from its precursor canthaxanthin and enhances gap junctional communication in 10T1/2 cells. Adv Exp Med Biol. 1996;387:121-8.
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