Amelubant (BIIL 284) (Synonyms: BIIL 284) |
| カタログ番号GC32058 |
Amelubant (BIIL 284) (BIIL 284) は、強力な経口の長時間作用型 LTB4 受容体アンタゴニストであり、LTB4 受容体にほとんど結合せず、重要な細胞および膜で 221 nM および 230 nM の Kis を示します。
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Cas No.: 346735-24-8
Sample solution is provided at 25 µL, 10mM.
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Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1].
Amelubant is a prodrug of active metabolites BIIL 260 and BIIL 315, which are reversible and competitive LTB4 receptor antagonists, with Kis of 1.4, 1.1 nM and 1.7, 1.9 nM in vital cells and membranes, respectively[1].
[1]. Birke FW, et al. In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66.
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