Amino-PEG6-alcohol |
| カタログ番号GC65840 |
Amino-PEG6-alcohol は、抗体薬物複合体 (ADC) の合成に使用される非切断型 6 ユニット PEG ADC リンカーです。アミノ-PEG6-アルコールは、PROTACの合成に使用できるPEGベースのPROTACリンカーでもあります。
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Cas No.: 39160-70-8
Sample solution is provided at 25 µL, 10mM.
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Amino-PEG6-alcohol is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG6-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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