Amitriptyline (Synonyms: MK-230, N-750, Ro41575) |
カタログ番号GC25060
One-Click Copy Product Info
|
アミトリプチリン（MK-230、N-750、Ro41575）は、抗うつ薬であり鎮痛作用がある三環系抗うつ薬（TCA）であり、うつ病や神経障害性疼痛の治療に広く使用されています。アミトリプチリンはセロトニン再取り込み阻害剤（SERT）およびノルエピネフリン再取り込み阻害剤（NET）の両方をKi値3.45nMおよび13.3nMで阻害します。また、アミトリプチリンはhistamine receptor H1, histamine receptor H4, 5-HT2およびsigma 1 receptorもそれぞれKi値0.5 nM, 7.31 nM, 235 nM and 287 nMで阻害します。この製品はろう質固体です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 50-48-6
Sample solution is provided at 25 µL, 10mM.
Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid.
| Cas No. | 50-48-6 | SDF | |
| 同義語 | MK-230, N-750, Ro41575 | ||
| Formula | C20H23N | M.Wt | 277.4 |
| 溶解度 | DMSO : 100 mg/mL (360.49 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.6049 mL | 18.0245 mL | 36.049 mL |
| 5 mM | 721 μL | 3.6049 mL | 7.2098 mL |
| 10 mM | 360.5 μL | 1.8025 mL | 3.6049 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)