Amlodipine-d4 (maleate) |
| カタログ番号GC46845 |
アムロジピンの定量化のための内部標準
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1185246-15-4
Sample solution is provided at 25 µL, 10mM.
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Amlodipine-d4 is intended for use as an internal standard for the quantification of amlodipine by GC- or LC-MS. Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle.1 Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues.1 Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition in vitro and in vivo.2 Formulations containing amlodipine have been used in the treatment of hypertension.
1.Burges, R.A., Gardiner, D.G., Gwilt, M., et al.Calcium channel blocking properties of amlodipine in vascular smooth muscle and cardiac muscle in vitro: Evidence for voltage modulation of vascular dihydropyridine receptorsJ. Cardiovasc. Pharmacol.9(1)110-119(1987) 2.Mason, R.P., Marche, P., and Hintze, T.H.Novel vascular biology of third-generation L-type calcium channel antagonists: Ancillary actions of amlodipineArterioscler. Thromb. Vasc. Biol.23(12)2155-2163(2003)
| Cas No. | 1185246-15-4 | SDF | |
| Canonical SMILES | CC1=C(C(OC)=O)C(C2=C(Cl)C=CC=C2)C(C(OCC)=O)=C(COC([2H])([2H])C([2H])([2H])N)N1.OC(/C=C\C(O)=O)=O | ||
| Formula | C20H21ClD4N2O5.C4H4O4 | M.Wt | 529 |
| 溶解度 | DMSO: 30 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.8904 mL | 9.4518 mL | 18.9036 mL |
| 5 mM | 0.3781 mL | 1.8904 mL | 3.7807 mL |
| 10 mM | 0.189 mL | 0.9452 mL | 1.8904 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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