Ansatrienin A (Synonyms: Mycotrienin I) |
| カタログ番号GC42815 |
アンサトリエニンAは、S.から最初に単離されたアンサマイシン系抗生物質および抗真菌剤です。
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Cas No.: 82189-03-5
Sample solution is provided at 25 µL, 10mM.
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Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis. In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM). Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fluorouracil , cisplatin , bleomycin , mitomycin C , and 6-mercaptopurine. It is an oxidized form of ansatrienin B .
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