ASP-4058 hydrochloride |
| カタログ番号GC62851 |
ASP-4058 塩酸塩は、スフィンゴシン 1-リン酸受容体 1 および 5 (S1P1 および S1P5) に対する次世代の選択的経口活性アゴニストであり、げっ歯類の実験的自己免疫性脳脊髄炎を良好な安全性プロファイルで改善します 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 952510-14-4
Sample solution is provided at 25 µL, 10mM.
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ASP-4058 hydrochloride is a next-generation, selective and orally active agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile[1].
ASP4058 (p.o., daily for 21 days) hydrochloride reduces the clinical score in a dose-dependent manner and the cumulative clinical score from day 0 to 21 dpi at 0.03, 0.1 and 0.3 mg/kg are 15.5±1.48, 9.50±2.17 and 1.17±1.17, respectively, while that of vehicle-treated group is 15.5±0.619 in rats. ASP4058 prevents decreases in body weight of EAE rats[1].ASP4058 (p.o., daily for day 12 to day 45) hydrochloride maintains the clinical score at a relatively low level and the cumulative clinical scores (18-45 dpi) among the groups treated with 0.1 and 0.3 mg/kg dosages are 6.90±2.85 and 5.60±2.21, respectively in mice. The ED50 values for ASP4058 is 0.063 mg/kg[1].
[1]. Rie Yamamoto, et al. ASP4058, a Novel Agonist for Sphingosine 1-Phosphate Receptors 1 and 5, Ameliorates Rodent Experimental Autoimmune Encephalomyelitis with a Favorable Safety Profile. PLoS One. 2014 Oct 27;9(10):e110819.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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