BAY 60-2770 |
| カタログ番号GC65051 |
BAY 60-2770 は、強力で選択的な経口活性の可溶性グアニル酸シクラーゼ (sGC) 活性化剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1027642-43-8
Sample solution is provided at 25 µL, 10mM.
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BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect[1][2].
BAY 60-2770 (0.1-0.3 mg/Kg; p.o.) attenuates liver fibrosis in two rat models[1].BAY 60-2770 (1 mg/kg; p.o.; daily from the 10th to the 12th week) results in amelioration of bladder dysfunction in high-fat obese mice[2].
[1]. Knorr A, et al. Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis. Arzneimittelforschung. 2008;58(2):71-80.
[2]. Leiria LO, et al. The soluble guanylyl cyclase activator BAY 60-2770 ameliorates overactive bladder in obese mice. J Urol. 2014 Feb;191(2):539-47.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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