Bexagliflozin (Synonyms: THR-1442) |
| カタログ番号GC19065 |
ベキサグリフロジンは、SGLT1 / SGLT2におけるIC50値がそれぞれ5.6μM / 2nMである、強力かつ選択的なSGLT2阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1118567-05-7
Sample solution is provided at 25 µL, 10mM.
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Bexagliflozin is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 uM /2 nM in SGLT1 /SGLT2 respectively.target: SGLT2IC50: 5.6 uM (SGLT1)/ 2 nM (SGLT2)1) In normal rats and dogs a saturable urinary glucose excretion was produced with an ED50 of 0.38 and 0.09 mg/kg, respectively.2) EGT1442 significantly prolonged the median survival of SHRSP rats.3) EGT1442 dose-dependently reduced HbA1c and blood glucose concentration without affecting body mass or insulin level.
References:
[1]. Zhang W et al. EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats. Pharmacol Res. 2011 Apr;63(4):284-93.
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