BMS 345541 (trifluoroacetate salt) |
| カタログ番号GC42953 |
BMS 345541は、IκBキナーゼIKKαおよびIKKβの細胞浸透性阻害剤です（IC50値はそれぞれ4および0.3μM）。
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Sample solution is provided at 25 µL, 10mM.
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BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 µM). It is without effect against a panel of other serine/threonine and tyrosine kinases at 100 µM. BMS 345541 inhibits signaling through nuclear factor-κB (NF-κB) both in cells and in vivo, showing excellent pharmacokinetics in mice. It blocks joint inflammation and damage in collagen-induced arthritis in mice and induces apoptosis in melanoma cells both in vitro and in vivo. BMS 345541 is used to explore novel roles for IKK phosphorylation and NF-κB signaling.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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