Brazilein |
カタログ番号GC52101 |
ブラジレインは、Caesalpinia sappan L. から分離された重要な免疫抑制成分です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 600-76-0
Sample solution is provided at 25 µL, 10mM.
Brazilein is a phytochemical that has been found in C. sappan and has diverse biological activities.1,2,3,4 It is active against E. coli, P. aeruginosa, and methicillin-susceptible S. aureus (MSSA; MICs = 32, 512, and 512 µg/ml), as well as a panel of 10 clinical isolates of methicillin-resistant S. aureus (MRSA; MIC50s = 16-32 µg/ml).1 Brazilein (10 µM) inhibits LPS-induced nitric oxide (NO) production in J774A.1 cells.2 It is cytotoxic to HepG2, Hep3B, MDA-MB-231, MCF-7, A549, and Ca9-22 cancer cells (IC50s = 3.15, 3.42, 2.36, 3.96, 9.68, and 8.63 µg/ml, respectively).3 Brazilein (1-10 µg/ml) also inhibits the proliferation of isolated mouse spleen lymphocytes induced by concanavalin A .4
1.Zuo, G.Y., Han, Z.Q., Hao, X.Y., et al.Synergy of aminoglycoside antibiotics by 3-benzylchroman derivatives from the chinese drug Caesalpinia sappan against clinical methicillin-resistant Staphylococcus aureus (MRSA)Phytomedicine21(7)936-941(2014) 2.Sasaki, Y., Hosokawa, T., Nagai, M., et al.In vitro study for inhibition of NO production about constituents of Sappan LignumBiol. Pharm. Bull.30(1)193-196(2007) 3.Yen, C.-T., Nakagawa-Goto, K., Hwang, T.-L., et al.Antitumor agents. 271: Total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agentsBioorg. Med. Chem. Lett.20(3)1037-1039(2010) 4.Ye, M., Xie, W.-D., Lei, F., et al.Brazilein, an important immunosuppressive component from Caesalpinia sappan LInt. Immunopharmacol.6(3)426-432(2006)
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(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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