Bromelain |
| カタログ番号GC62536 |
ブロメラインはパイナップルの茎に由来する抗炎症薬で、血漿キニノーゲンのダウンレギュレーション、プロスタグランジン E2 発現の阻害、最終糖化産物受容体の分解、血管新生バイオマーカーの調節、および COX 経路の上流での抗酸化作用を通じて作用します。 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 9001-00-7
Sample solution is provided at 25 µL, 10mM.
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Bromelain is an anti-inflammatory drug derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway[1]. Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death[2].
Bromelain (40 mg/kg; intraperitoneal injection; daily; for 7 days; male Sprague-Dawley rats) pretreatment reduces the motor dysfunction in the parkinsonian rat model of parkinson’s disease (PD). 6-OHDA injection resulted in marked motor impairment which is prevented by pretreatment with Bromelain prior to the lesion[1].
[1]. Adu TS, et al. Effects of bromelain on motor responses following intra-medial forebrain bundle 6-OHDA injection in rat model of parkinsonism. Metab Brain Dis. 2019 Jul 22.
[2]. Pavan R, et al. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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