C-171 |
| カタログ番号GC46984 |
C-171 は、インターフェロン遺伝子刺激因子 (STING) の阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2244881-69-2
Sample solution is provided at 25 µL, 10mM.
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C-171 is an inhibitor of stimulator of interferon genes (STING).1,2 It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1.1 It selectively reduces human and mouse STING-, but not RIG-I or TBK1-, mediated IFN-β reporter activity in HEK293 cells when used at concentrations ranging from 0.02 to 2 μM.
1.Haag, S.M., Gulen, M.F., Reymond, L., et al.Targeting STING with covalent small-molecule inhibitorsNature559(7713)269-273(2018) 2.Zhang, H., You, Q.-D., and Xu, X.-L.Targeting stimulator of interferon genes (STING): A medicinal chemistry perspectiveJ. Med. Chem.63(8)3785-3816(2019)
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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