c-Kit-IN-5-1 |
カタログ番号GC65948
One-Click Copy Product Info
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c-Kit-IN-5 は c-Kit の強力な阻害剤であり、IC50 はキナーゼアッセイと細胞アッセイでそれぞれ 22 nM と 16 nM です。 c-Kit-IN-5 は、KDR、p38、Lck、および Src よりも 200 倍以上の c-Kit に対する選択性を示します。 c-Kit-IN-5 は、望ましい薬物動態特性も示します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1003311-62-3
Sample solution is provided at 25 µL, 10mM.
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c-Kit-IN-5 is potent inhibitor of c-Kit, with IC50s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties[1].
c-Kit-IN-5 (compound 25) shows more than 200-fold selectivity against KDR, p38, Lck, and Src (IC50=>5.0, 40, 7.8 , and >5.0 μM, respectively)[1].
c-Kit-IN-5 (compound 25) (1 mg/kg; i.v.) exhibits CL (0.46 L/h/kg) and Vdss (1.59 L/kg) in rats[1].
c-Kit-IN-5 (10 mg/kg; p.o.) exhibits AUC0-t(9860 ng•h/mL) Cmax(1230 ng/mL), T1/2 (2.6 h), and F (39%) in rats[1].
| Cas No. | 1003311-62-3 | SDF | |
| Formula | C23H17N5O2 | M.Wt | 395.41 |
| 溶解度 | DMSO : 25 mg/mL (63.23 mM; ultrasonic and warming and heat to 80°C) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.529 mL | 12.6451 mL | 25.2902 mL |
| 5 mM | 505.8 μL | 2.529 mL | 5.058 mL |
| 10 mM | 252.9 μL | 1.2645 mL | 2.529 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)