Carboxyphosphamide (Synonyms: CPCOOH, NSC 145124) |
| カタログ番号GC49147 |
シクロホスファミドの不活性代謝物
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Cas No.: 22788-18-7
Sample solution is provided at 25 µL, 10mM.
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Carboxyphosphamide is an inactive metabolite of the alkylating agent cyclophosphamide .1 It is formed from cyclophosphamide via oxidation of the intermediate metabolite aldophosphamide by aldehyde dehydrogenase.
1.Manthey, C.L., and Sladek, N.E.Kinetic characterization of the catalysis of "activated" cyclophosphamide (4-hydroxycyclophosphamide/aldophosphamide) oxidation to carboxyphosphamide by mouse hepatic aldehyde dehydrogenasesBiochem. Pharmacol.37(14)2781-2790(1988)
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