Atrial Natriuretic Peptide (1-28) (rat) (trifluoroacetate salt) (Synonyms: ANF, ANP, Atrial Natriuretic Factor, α-Atriopeptin (rat)) |
| カタログ番号GC42871 |
心臓の心筋細胞によって分泌される、プレプロ-ANPのプロテオリシスによって生成された内因性ペプチドである心房性ナトリウム利尿ペプチド（ANP）です。
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Sample solution is provided at 25 µL, 10mM.
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Atrial natriuretic peptide (ANP) is an endogenous peptide generated by proteolysis of prepro-ANP that is secreted by cardiomyocytes in the heart. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, inhibit renin secretion, and increase sodium excretion. In rat kidney cortex ex vivo, exogenous rat ANP inhibits basal renin release in a dose-dependent manner and inhibits renin release induced by isoproterenol with an IC50 value of 58 nM. ANP (8 µg/kg) decreases plasma renin activity and cAMP levels in anesthetized rats and increases cGMP levels. It also inhibits arginine vasopressin-induced increases in mean arterial blood pressure in spontaneously hypertensive and control rats when administered intracerebroventricularly at a dose of 150 ng. ANP (1-28) (rat) is a 28 amino acid peptide corresponding to the rat protein sequence.
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