(Met¹⁸⁶)-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse) |
カタログ番号GA20255 |
このgp100エピトープgp(209-217)(H-4106)の修飾された配列では、2番目の天門酸が自然なメチオニンに置き換えられており、未修飾ペプチドよりもHLA-A2分子に高い親和性を示し、末梢血単核細胞の感作に使用される場合、増加した能力でメラノーマ反応性細胞傷害性Tリンパ球(CTL)を生成することが示されました。この合成ペプチドは新しいがん免疫療法の開発に有望です。
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Cas No.: 181477-43-0
Sample solution is provided at 25 µL, 10mM.
This modified sequence of the gp100 epitope gp(209-217), in which a methionine replaced the natural threonine at position 2, bound to the HLA-A2 molecule with greater affinity than the unmodified peptide and was shown to have an increased ability to ge
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