CBM 301940 |
| カタログ番号GC50421 |
強力なマロニル-CoA脱炭酸酵素阻害剤。経口摂取可能。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 902146-11-6
Sample solution is provided at 25 µL, 10mM.
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Potent malonyl-CoA decarboxylase (MCD) inhibitor (IC50 = 23 nM). Suppresses malonyl-CoA degradation and fatty acid oxidation in isolated rat hearts, leading to secondary increase in glucose oxidation. Improves cardiac function during reperfusion of ischemic isolated rat hearts. Orally bioavailable.
Dyck et al (2004) Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ.Res. 94 e78 PMID:15105298 |Cheng et al (2006) Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J.Med.Chem. 49 4055 PMID:16821767
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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