GLPG1205 |
| カタログ番号GC39385 |
GLPG1205 は、良好な PK/PD プロファイルを持つ強力で選択的な経口活性 GPR84 (G タンパク質共役受容体) アンタゴニストです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1445847-37-9
Sample solution is provided at 25 µL, 10mM.
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GLPG1205 is potent, selective and orally active GPR84 (a G-protein-coupled receptor) antagonist with a favorable PK/PD profile. GLPG1205 has anti-inflammatory activity and is used for the treatment of pulmonary fibrosis[1][2].
[1]. Sundqvist M, et al. Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor FFA2R. Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):695-708. [2]. F. Vanhoutte, et al. Human safety, pharmacokinetics and pharmacodynamics of the GPR84 antagonist GLPG1205, a potential new approach to treat IBD. [3]. L.Saniere, et al. Characterization of GLPG1205 in Mouse Fibrosis Models: A Potent and Selective Antagonist of GPR84 for Treatment of Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine 2019;199:A1046 [4]. F. Vanhoutte, et al. Human safety, pharmacokinetics and pharmacodynamics
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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